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Review Article

饮食与心血管疾病：食物和营养物质对古典和新兴心血管疾病危险因素的影响

卷 26, 期 19, 2019

页: [3639 - 3651] 页: 13

弟呕挨: 10.2174/0929867324666170428103206

价格: $65

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摘要

心血管疾病（CVD）是全球死亡的主要原因。 饮食包括对人类健康有影响的食物化合物的混合物。 饮食与健康之间的关系极其复杂，延迟或预防诸如CVD之类的慢性疾病的策略尤为重要，因为慢性疾病和更具体的CVD仍是全世界死亡和致残的主要原因。 在本小型审查中，我们旨在总结有关潜在影响CVD发生和发展的主要饮食成分的当前知识。 当前的研究称富含水果和蔬菜的地中海饮食模式对心脏最有保护作用，因为它具有高浓度的生物活性化合物，例如不饱和脂肪酸，多酚，纤维，植物甾醇，维生素和矿物质，可发挥抗氧化，抗氧化作用。 炎症和抗血栓形成作用导致CVD起始和进展的延迟。

关键词: 心血管疾病，危险因素，抗氧化剂，脂肪酸，多酚，地中海饮食，胆固醇，炎症。

« Previous Next »
[1]
Keys, A.; Menotti, A.; Karvonen, M.J.; Aravanis, C.; Blackburn, H.; Buzina, R.; Djordjevic, B.S.; Dontas, A.S.; Fidanza, F.; Keys, M.H.; Kromhout, D.; Nedeljkovic, S.; Punsar, S.; Seccareccia, F.; Toshima, H. The diet and 15-year death rate in the seven countries study. Am. J. Epidemiol., 1986, 124(6), 903-915.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a114480] [PMID: 3776973]
[2]
Badimon, L.; Vilahur, G.; Padro, T. Systems biology approaches to understand the effects of nutrition and promote health. Br. J. Clin. Pharmacol., 2017, 83(1), 38-45.
[http://dx.doi.org/10.1111/bcp.12965] [PMID: 27062443]
[3]
Micha, R.; Mozaffarian, D. Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: a fresh look at the evidence. Lipids, 2010, 45(10), 893-905.
[http://dx.doi.org/10.1007/s11745-010-3393-4] [PMID: 20354806]
[4]
Nettleton, J.A.; Lovegrove, J.A.; Mensink, R.P.; Schwab, U. Dietary Fatty Acids: Is it Time to Change the Recommendations? Ann. Nutr. Metab., 2016, 68(4), 249-257.
[http://dx.doi.org/10.1159/000446865] [PMID: 27251664]
[5]
Baer, D.J.; Judd, J.T.; Clevidence, B.A.; Tracy, R.P. Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. Am. J. Clin. Nutr., 2004, 79(6), 969-973.
[http://dx.doi.org/10.1093/ajcn/79.6.969] [PMID: 15159225]
[6]
Pararasa, C.; Bailey, C.; Griffiths, H. Macrophage polarisation by fatty acids is PPARgamma-dependent. Free Radic. Biol. Med., 2014, 75(Suppl. 1), S31-S32.
[http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.764] [PMID: 26461339]
[7]
Lee, J.Y.; Zhao, L.; Youn, H.S.; Weatherill, A.R.; Tapping, R.; Feng, L.; Lee, W.H.; Fitzgerald, K.A.; Hwang, D.H. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J. Biol. Chem., 2004, 279(17), 16971-16979.
[http://dx.doi.org/10.1074/jbc.M312990200] [PMID: 14966134]
[8]
Wen, H.; Gris, D.; Lei, Y.; Jha, S.; Zhang, L.; Huang, M.T.; Brickey, W.J.; Ting, J.P. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol., 2011, 12(5), 408-415.
[http://dx.doi.org/10.1038/ni.2022] [PMID: 21478880]
[9]
Vafeiadou, K.; Weech, M.; Altowaijri, H.; Todd, S.; Yaqoob, P.; Jackson, K.G.; Lovegrove, J.A. Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers, E-selectin, and blood pressure: results from the randomized, controlled dietary intervention and vascular function (DIVAS) study. Am. J. Clin. Nutr., 2015, 102(1), 40-48.
[http://dx.doi.org/10.3945/ajcn.114.097089] [PMID: 26016869]
[10]
Perdomo, L.; Beneit, N.; Otero, Y.F.; Escribano, Ó.; Díaz-Castroverde, S.; Gómez-Hernández, A.; Benito, M. Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process. Cardiovasc. Diabetol., 2015, 14, 75.
[http://dx.doi.org/10.1186/s12933-015-0237-9] [PMID: 26055507]
[11]
L’homme, L.; Esser, N.; Riva, L.; Scheen, A.; Paquot, N.; Piette, J.; Legrand-Poels, S. Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages. J. Lipid Res., 2013, 54(11), 2998-3008.
[http://dx.doi.org/10.1194/jlr.M037861] [PMID: 24006511]
[12]
Dyerberg, J.; Bang, H.O.; Stoffersen, E.; Moncada, S.; Vane, J.R. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet, 1978, 2(8081), 117-119.
[http://dx.doi.org/10.1016/S0140-6736(78)91505-2] [PMID: 78322]
[13]
Endo, J.; Arita, M. Cardioprotective mechanism of omega-3 polyunsaturated fatty acids. J. Cardiol., 2016, 67(1), 22-27.
[http://dx.doi.org/10.1016/j.jjcc.2015.08.002] [PMID: 26359712]
[14]
Mozaffarian, D.; Wu, J.H. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J. Am. Coll. Cardiol., 2011, 58(20), 2047-2067.
[http://dx.doi.org/10.1016/j.jacc.2011.06.063] [PMID: 22051327]
[15]
Kris-Etherton, P.M.; Harris, W.S.; Appel, L.J. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation, 2002, 106(21), 2747-2757.
[http://dx.doi.org/10.1161/01.CIR.0000038493.65177.94] [PMID: 12438303]
[16]
Xiao, Y.F.; Kang, J.X.; Morgan, J.P.; Leaf, A. Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes. Proc. Natl. Acad. Sci. USA, 1995, 92(24), 11000-11004.
[http://dx.doi.org/10.1073/pnas.92.24.11000] [PMID: 7479925]
[17]
Griffin, M.D.; Sanders, T.A.; Davies, I.G.; Morgan, L.M.; Millward, D.J.; Lewis, F.; Slaughter, S.; Cooper, J.A.; Miller, G.J.; Griffin, B.A. Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. Am. J. Clin. Nutr., 2006, 84(6), 1290-1298.
[http://dx.doi.org/10.1093/ajcn/84.6.1290] [PMID: 17158408]
[18]
Kim, Y.; Je, Y. Dietary fibre intake and mortality from cardiovascular disease and all cancers: A meta-analysis of prospective cohort studies. Arch. Cardiovasc. Dis., 2016, 109(1), 39-54.
[http://dx.doi.org/10.1016/j.acvd.2015.09.005] [PMID: 26711548]
[19]
Aleixandre, A.; Miguel, M. Dietary fiber and blood pressure control. Food Funct., 2016, 7(4), 1864-1871.
[http://dx.doi.org/10.1039/C5FO00950B] [PMID: 26923351]
[20]
Koh, A.; De Vadder, F.; Kovatcheva-Datchary, P.; Bäckhed, F. From Dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell, 2016, 165(6), 1332-1345.
[http://dx.doi.org/10.1016/j.cell.2016.05.041] [PMID: 27259147]
[21]
Hartley, L.; May, M.D.; Loveman, E.; Colquitt, J.L.; Rees, K. Dietary fibre for the primary prevention of cardiovascular disease. Cochrane Database Syst. Rev., 2016, (1)CD011472
[http://dx.doi.org/10.1002/14651858.CD011472.pub2] [PMID: 26758499]
[22]
Kimura, I.; Ozawa, K.; Inoue, D.; Imamura, T.; Kimura, K.; Maeda, T.; Terasawa, K.; Kashihara, D.; Hirano, K.; Tani, T.; Takahashi, T.; Miyauchi, S.; Shioi, G.; Inoue, H.; Tsujimoto, G. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat. Commun., 2013, 4, 1829.
[http://dx.doi.org/10.1038/ncomms2852] [PMID: 23652017]
[23]
Halliwell, B.; Gutteridge, J.M.C. Free Radicals in Biology and Medicine; Clarendon Press: Oxford, 1999.
[24]
Halliwell, B. The antioxidant paradox. Lancet, 2000, 355(9210), 1179-1180.
[http://dx.doi.org/10.1016/S0140-6736(00)02075-4] [PMID: 10791396]
[25]
Livingston, C.J.; Freeman, R.J.; Mohammad, A.; Costales, V.C.; Titus, T.M.; Harvey, B.J.; Sherin, K.M. Choosing Wisely Task, F. Choosing Wisely(R) in Preventive Medicine: The American College of Preventive Medicine’s Top 5 List of Recommendations. Am. J. Prev. Med., 2016, 51(1), 141-149.
[http://dx.doi.org/10.1016/j.amepre.2016.03.009] [PMID: 27155735]
[26]
May, J.M.; Harrison, F.E. Role of vitamin C in the function of the vascular endothelium. Antioxid. Redox Signal., 2013, 19(17), 2068-2083.
[http://dx.doi.org/10.1089/ars.2013.5205] [PMID: 23581713]
[27]
Ashor, A.W.; Lara, J.; Mathers, J.C.; Siervo, M. Effect of vitamin C on endothelial function in health and disease: a systematic review and meta-analysis of randomised controlled trials. Atherosclerosis, 2014, 235(1), 9-20.
[http://dx.doi.org/10.1016/j.atherosclerosis.2014.04.004] [PMID: 24792921]
[28]
Mathur, P.; Ding, Z.; Saldeen, T.; Mehta, J.L. Tocopherols in the prevention and treatment of atherosclerosis and related cardiovascular disease. Clin. Cardiol., 2015, 38(9), 570-576.
[http://dx.doi.org/10.1002/clc.22422] [PMID: 26272221]
[29]
Ricciarelli, R.; Zingg, J.M.; Azzi, A. Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells. Circulation, 2000, 102(1), 82-87.
[http://dx.doi.org/10.1161/01.CIR.102.1.82] [PMID: 10880419]
[30]
Chiva-Blanch, G.; Visioli, F. Polyphenols and health: Moving beyond antioxidants. J. Berry Res., 2012, 2, 9.
[31]
Upadhyay, S.; Dixit, M. Role of polyphenols and other phytochemicals on molecular signaling. Oxid. Med. Cell. Longev., 2015.2015504253
[http://dx.doi.org/10.1155/2015/504253] [PMID: 26180591]
[32]
El Haouari, M.; Rosado, J.A. Medicinal plants with antiplatelet activity. Phytother. Res., 2016, 30(7), 1059-1071.
[http://dx.doi.org/10.1002/ptr.5619] [PMID: 27062716]
[33]
Du, G.; Sun, L.; Zhao, R.; Du, L.; Song, J.; Zhang, L.; He, G.; Zhang, Y.; Zhang, J. Polyphenols: potential source of drugs for the treatment of ischaemic heart disease. Pharmacol. Ther., 2016, 162, 23-34.
[http://dx.doi.org/10.1016/j.pharmthera.2016.04.008] [PMID: 27113411]
[34]
Fitzpatrick, D.F.; Hirschfield, S.L.; Coffey, R.G. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am. J. Physiol., 1993, 265(2 Pt 2), H774-H778.
[PMID: 8396352]
[35]
Hügel, H.M.; Jackson, N.; May, B.; Zhang, A.L.; Xue, C.C. Polyphenol protection and treatment of hypertension. Phytomedicine, 2016, 23(2), 220-231.
[http://dx.doi.org/10.1016/j.phymed.2015.12.012] [PMID: 26926184]
[36]
Alissa, E.M.; Ferns, G.A. Dietary fruits and vegetables and cardiovascular diseases risk. Crit. Rev. Food Sci. Nutr., 2017, 57(9), 1950-1962.
[PMID: 26192884]
[37]
Helnæs, A.; Kyrø, C.; Andersen, I.; Lacoppidan, S.; Overvad, K.; Christensen, J.; Tjønneland, A.; Olsen, A. Intake of whole grains is associated with lower risk of myocardial infarction: the danish diet, cancer and health cohort. Am. J. Clin. Nutr., 2016, 103(4), 999-1007.
[http://dx.doi.org/10.3945/ajcn.115.124271] [PMID: 26888710]
[38]
Hollænder, P.L.; Ross, A.B.; Kristensen, M. Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies. Am. J. Clin. Nutr., 2015, 102(3), 556-572.
[http://dx.doi.org/10.3945/ajcn.115.109165] [PMID: 26269373]
[39]
Mellen, P.B.; Walsh, T.F.; Herrington, D.M. Whole grain intake and cardiovascular disease: a meta-analysis. Nutr. Metab. Cardiovasc. Dis., 2008, 18(4), 283-290.
[http://dx.doi.org/10.1016/j.numecd.2006.12.008] [PMID: 17449231]
[40]
Mudryj, A.N.; Yu, N.; Aukema, H.M. Nutritional and health benefits of pulses. Appl. Physiol. Nutr. Metab., 2014, 39(11), 1197-1204.
[http://dx.doi.org/10.1139/apnm-2013-0557] [PMID: 25061763]
[41]
Eslamparast, T.; Sharafkhah, M.; Poustchi, H.; Hashemian, M.; Dawsey, S.M.; Freedman, N.D.; Boffetta, P.; Abnet, C.C.; Etemadi, A.; Pourshams, A.; Malekshah, A.F.; Islami, F.; Kamangar, F.; Merat, S.; Brennan, P.; Hekmatdoost, A.; Malekzadeh, R. Nut consumption and total and cause-specific mortality: results from the Golestan Cohort Study. Int. J. Epidemiol., 2017, 46(1), 75-85.
[PMID: 26946539]
[42]
Del Gobbo, L.C.; Falk, M.C.; Feldman, R.; Lewis, K.; Mozaffarian, D. Effects of tree nuts on blood lipids, apolipoproteins, and blood pressure: systematic review, meta-analysis, and dose-response of 61 controlled intervention trials. Am. J. Clin. Nutr., 2015, 102(6), 1347-1356.
[http://dx.doi.org/10.3945/ajcn.115.110965] [PMID: 26561616]
[43]
Lippi, G.; Cervellin, G.; Mattiuzzi, C. More pistachio nuts for improving the blood lipid profile. Systematic review of epidemiological evidence. Acta Biomed., 2016, 87(1), 5-12.
[PMID: 27163889]
[44]
Kasliwal, R.R.; Bansal, M.; Mehrotra, R.; Yeptho, K.P.; Trehan, N. Effect of pistachio nut consumption on endothelial function and arterial stiffness. Nutrition, 2015, 31(5), 678-685.
[http://dx.doi.org/10.1016/j.nut.2014.10.019] [PMID: 25837212]
[45]
Carughi, A.; Feeney, M.J.; Kris-Etherton, P.; Fulgoni, V., III; Kendall, C.W.; Bulló, M.; Webb, D. Pairing nuts and dried fruit for cardiometabolic health. Nutr. J., 2016, 15, 23.
[http://dx.doi.org/10.1186/s12937-016-0142-4] [PMID: 26944400]
[46]
Mayhew, A.J.; de Souza, R.J.; Meyre, D.; Anand, S.S.; Mente, A. A systematic review and meta-analysis of nut consumption and incident risk of CVD and all-cause mortality. Br. J. Nutr., 2016, 115(2), 212-225.
[http://dx.doi.org/10.1017/S0007114515004316] [PMID: 26548503]
[47]
Covas, M.I.; Nyyssönen, K.; Poulsen, H.E.; Kaikkonen, J.; Zunft, H.J.; Kiesewetter, H.; Gaddi, A.; de la Torre, R.; Mursu, J.; Bäumler, H.; Nascetti, S.; Salonen, J.T.; Fitó, M.; Virtanen, J.; Marrugat, J.; Group, E.S. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann. Intern. Med., 2006, 145(5), 333-341.
[http://dx.doi.org/10.7326/0003-4819-145-5-200609050-00006] [PMID: 16954359]
[48]
Gil, A.; Gil, F. Fish, a Mediterranean source of n-3 PUFA: benefits do not justify limiting consumption. Br. J. Nutr., 2015, 113(Suppl. 2), S58-S67.
[http://dx.doi.org/10.1017/S0007114514003742] [PMID: 26148923]
[49]
Sala-Vila, A.; Guasch-Ferré, M.; Hu, F.B.; Sánchez-Tainta, A.; Bulló, M.; Serra-Mir, M.; López-Sabater, C.; Sorlí, J.V.; Arós, F.; Fiol, M.; Muñoz, M.A.; Serra-Majem, L.; Martínez, J.A.; Corella, D.; Fitó, M.; Salas-Salvadó, J.; Martínez-González, M.A.; Estruch, R.; Ros, E.B Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study J. Am. Heart Assoc., 2016, 5(1), e002543.
[http://dx.doi.org/10.1161/JAHA.115.002543] [PMID: 26813890]
[50]
Megdal, P.A.; Craft, N.A.; Handelman, G.J. A simplified method to distinguish farmed (Salmo salar) from wild salmon: fatty acid ratios versus astaxanthin chiral isomers. Lipids, 2009, 44(6), 569-576.
[http://dx.doi.org/10.1007/s11745-009-3294-6] [PMID: 19452184]
[51]
Raymond, M.R.; Christensen, K.Y.; Thompson, B.A.; Anderson, H.A. Associations between fish consumption and contaminant biomarkers with cardiovascular conditions among older male anglers in wisconsin. J. Occup. Environ. Med., 2016, 58(7), 676-682.
[http://dx.doi.org/10.1097/JOM.0000000000000757] [PMID: 27253229]
[52]
Rhee, J.J.; Qin, F.; Hedlin, H.K.; Chang, T.I.; Bird, C.E.; Zaslavsky, O.; Manson, J.E.; Stefanick, M.L.; Winkelmayer, W.C. Coffee and caffeine consumption and the risk of hypertension in postmenopausal women. Am. J. Clin. Nutr., 2016, 103(1), 210-217.
[http://dx.doi.org/10.3945/ajcn.115.120147] [PMID: 26657046]
[53]
Kučera, L.; Papoušek, R.; Kurka, O.; Barták, P.; Bednář, P. Study of composition of espresso coffee prepared from various roast degrees of Coffea arabica L. coffee beans. Food Chem., 2016, 199, 727-735.
[http://dx.doi.org/10.1016/j.foodchem.2015.12.080] [PMID: 26776030]
[54]
Higdon, J.V.; Frei, B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr., 2003, 43(1), 89-143.
[http://dx.doi.org/10.1080/10408690390826464] [PMID: 12587987]
[55]
Chowdhury, A.; Sarkar, J.; Chakraborti, T.; Pramanik, P.K.; Chakraborti, S. Protective role of epigallocatechin-3-gallate in health and disease: A perspective. Biomed. Pharmacother., 2016, 78, 50-59.
[http://dx.doi.org/10.1016/j.biopha.2015.12.013] [PMID: 26898424]
[56]
Database on polyphenols content of foods. Available at: . http://phenol-explorer.eu/ [Accessed: June 27, 2016]
[57]
Loffredo, L.; Perri, L.; Nocella, C.; Violi, F. Antioxidant and antiplatelet activity by polyphenol-rich nutrients: focus on extra virgin olive oil and cocoa. Br. J. Clin. Pharmacol., 2017, 83(1), 96-102.
[http://dx.doi.org/10.1111/bcp.12923] [PMID: 26922974]
[58]
de Gaetano, G.; Costanzo, S.; Di Castelnuovo, A.; Badimon, L.; Bejko, D.; Alkerwi, A.; Chiva-Blanch, G.; Estruch, R.; La Vecchia, C.; Panico, S.; Pounis, G.; Sofi, F.; Stranges, S.; Trevisan, M.; Ursini, F.; Cerletti, C.; Donati, M.B.; Iacoviello, L. Effects of moderate beer consumption on health and disease: A consensus document. Nutr. Metab. Cardiovasc. Dis., 2016, 26(6), 443-467.
[http://dx.doi.org/10.1016/j.numecd.2016.03.007] [PMID: 27118108]
[59]
Chiva-Blanch, G.; Magraner, E.; Condines, X.; Valderas-Martínez, P.; Roth, I.; Arranz, S.; Casas, R.; Navarro, M.; Hervas, A.; Sisó, A.; Martínez-Huélamo, M.; Vallverdú-Queralt, A.; Quifer-Rada, P.; Lamuela-Raventos, R.M.; Estruch, R. Effects of alcohol and polyphenols from beer on atherosclerotic biomarkers in high cardiovascular risk men: a randomized feeding trial. Nutr. Metab. Cardiovasc. Dis., 2015, 25(1), 36-45.
[http://dx.doi.org/10.1016/j.numecd.2014.07.008] [PMID: 25183453]
[60]
Vilahur, G.; Casani, L.; Mendieta, G.; Lamuela-Raventos, R.M.; Estruch, R.; Badimon, L. Beer elicits vasculoprotective effects through Akt/eNOS activation. Eur. J. Clin. Invest., 2014, 44(12), 1177-1188.
[http://dx.doi.org/10.1111/eci.12352] [PMID: 25323945]
[61]
Llorente-Cortés, V.; Estruch, R.; Mena, M.P.; Ros, E.; González, M.A.; Fitó, M.; Lamuela-Raventós, R.M.; Badimon, L. Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk. Atherosclerosis, 2010, 208(2), 442-450.
[http://dx.doi.org/10.1016/j.atherosclerosis.2009.08.004] [PMID: 19712933]
[62]
Bonaccio, M.; Pounis, G.; Cerletti, C.; Donati, M.B.; Iacoviello, L.; de Gaetano, G. Mediterranean diet, dietary polyphenols and low-grade inflammation: results from the moli-sani study. Br. J. Clin. Pharmacol., 2017, 83(1), 107-113.
[http://dx.doi.org/10.1111/bcp.12924] [PMID: 26935858]
[63]
Estruch, R.; Ros, E.; Salas-Salvado, J.; Covas, M.I.; Corella, D.; Aros, F.; Gomez-Gracia, E.; Ruiz-Gutierrez, V.; Fiol, M.; Lapetra, J.; Lamuela Raventos, R.M. Serra- Majem, L.; Pinto, X.; Basora, J.; Munoz, M. A.; Sorli, J. V.; Martinez, J. A.; Martinez-Gonzalez, M. A. Primary prevention of cardiovascular disease with a mediterranean diet supplemented with extra-virgin olive oil or nuts. N. Engl. J. Med., 2018, 378(25)e34
[64]
Stewart, R.A.; Wallentin, L.; Benatar, J.; Danchin, N.; Hagström, E.; Held, C.; Husted, S.; Lonn, E.; Stebbins, A.; Chiswell, K.; Vedin, O.; Watson, D.; White, H.D. Dietary patterns and the risk of major adverse cardiovascular events in a global study of high-risk patients with stable coronary heart disease. Eur. Heart J., 2016, 37(25), 1993-2001.
[http://dx.doi.org/10.1093/eurheartj/ehw125] [PMID: 27109584]
[65]
United Nations Educational, Scientific and Cultural Organization (UNESCO). Available at:. http://www.unesco.org/culture/ich/en/RL/mediterraneandiet-00884 [Accessed: June 27, 2016]
[66]
Dinu, M.; Abbate, R.; Gensini, G.F.; Casini, A.; Sofi, F. Vegetarian, vegan diets and multiple health outcomes: a systematic review with meta-analysis of observational studies. Crit. Rev. Food Sci. Nutr., 2017, 57(17), 3640-3649.
[http://dx.doi.org/dx. doi: 10.1080/10408398.2016.1138447] [PMID: 26853923]
[67]
Sofi, F.; Dinu, M.; Pagliai, G.; Cesari, F.; Marcucci, R.; Casini, A. Mediterranean versus vegetarian diet for cardiovascular disease prevention (the CARDIVEG study): study protocol for a randomized controlled trial. Trials, 2016, 17(1), 233.
[http://dx.doi.org/10.1080/10408398.2016.1138447] [PMID: 26853923]
[68]
Appleby, P.N.; Crowe, F.L.; Bradbury, K.E.; Travis, R.C.; Key, T.J. Mortality in vegetarians and comparable nonvegetarians in the United Kingdom. Am. J. Clin. Nutr., 2016, 103(1), 218-230.
[http://dx.doi.org/10.3945/ajcn.115.119461] [PMID: 26657045]
[69]
Roswall, N.; Sandin, S.; Löf, M.; Skeie, G.; Olsen, A.; Adami, H.O.; Weiderpass, E. Adherence to the healthy Nordic food index and total and cause-specific mortality among Swedish women. Eur. J. Epidemiol., 2015, 30(6), 509-517.
[http://dx.doi.org/10.1007/s10654-015-0021-x] [PMID: 25784368]
[70]
Hu, F.B.; Willett, W.C. Optimal diets for prevention of coronary heart disease. JAMA, 2002, 288(20), 2569-2578.
[PMID: 21346102]
[71]
Olsen, A.; Egeberg, R.; Halkjaer, J.; Christensen, J.; Overvad, K.; Tjonneland, A. Healthy aspects of the Nordic diet are related to lower total mortality. J. Nutr., 2011, 141(4), 639-644.
[PMID: 21346102]

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