Title:Predicting S-sulfenylation Sites Using Physicochemical Properties Differences
Volume: 14
Issue: 9
Author(s): Guo-Cheng Lei, Jijun Tang and Pu-Feng Du*
Affiliation:
- School of Computer Science and Technology, Tianjin University, Tianjin 300350,China
Keywords:
S-sulfenylation sites, physicochemical properties difference, partition the training set, voting scheme, sequence
segments, ensemble classifier.
Abstract: Protein S-sulfenylation plays a critical role in pathology and physiology. Detecting
S-sulfenylated proteins in cells is of great value in medical and life sciences. Several computational methods
have been developed to predict S-sulfenylation sites. However, the prediction performances are still
not ideal.
Method: We developed a computational method to predict S-sulfenylation sites by utilizing physicochemical
property differences to represent sequence segments around S-sulfenylation sites. By using a
clustering method to partition the training set, we developed a novel prediction method using an ensemble
classifier.
Results: Our method achieves an overall accuracy of 69.88% on the benchmarking dataset. We compared
our method to the other state-of-the-art methods. Our method performs better than all existing methods.
Conclusion: We proposed a computational method to predict S-sulfenylated sites, which outperforms
other state-of-the-art methods.
