Title:Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy
Volume: 24
Issue: 28
关键词:
血管紧张素II，食糜酶，糖尿病性视网膜病变，神经变性，氧化应激，肾素 - 血管紧张素系统，视网膜。
摘要: Diabetic retinopathy (DR) is a major diabetes complication and the leading
cause for vision loss and blindness in the adult human population. Diabetes, being an endocrinological
disorder dysregulates a number of hormonal systems including the renin
angiotensin system (RAS), which thereby may damage both vascular and neuronal cells
in the retina. Angiotensin II (Ang II), an active component of the RAS is increased in diabetic
retina, and may play a significant role in neurovascular damage leading to the progression
of DR. In this review article, we highlight the role of Ang II in the pathogenesis
of retinal damage in diabetes and discuss a newly identified mechanism involving tissue
chymase and angiotensin-(1-12) [Ang-(1-12)] pathways. We also discuss the therapeutic
effects of potential RAS inhibitors targeting blockade of cellular Ang II formation to prevent/
protect the retinal damage. Thus, a better understanding of Ang II formation pathways
in the diabetic retina will elucidate early molecular mechanism of vision loss. These
concepts may provide a novel strategy for preventing and/or treating diabetic retinopathy,
a leading cause of blindness worldwide.
