Title:Myocardial Infarction. Pathological Relevance and Relationship with Coronary Risk Factors
Volume: 23
Issue: 22
Author(s): Aurelio Leone*
Affiliation:
Keywords:
Myocardial infarction, coronary pathology, sympathetic nervous system, catecholamine release, myocardial necrosis, coronary
risk factor(s).
Abstract: Background: Three types of necrosis characterize MI: coagulation necrosis, typically due to a
coronarogenic mechanism, coagulative myocytolysis with formation of contract bands as an effect of sympathetic
nervous system and adrenergic stimulation, and colliquative myocytolysis, characterized by myocardial fiber
lysis, which is a close result of hydrolytic enzyme activity deriving from the material reaching the infarct area.
Methods: Although a multifactorial etiology may be identified, nevertheless coronary alterations, which are a
consequence of atherosclerotic plaque formation and complications with a reduced blood flow supply to the myocardium,
are the benchmark of MI.
Results: Evidence indicates a close relationship between the MI and some coronary risk factors, associated with
this pathologic pattern with a different, but high rate.
Conclusion: Precipitating events to cause acute myocardial pathology need, however, to develop an acute myocardial
infarction.
