Title:Role of Oxidative Stress in Renal Transplantation: Bases for an n-3 PUFA Strategy Against Delayed Graft Function
Volume: 24
Issue: 14
关键词:
氧化应激，活性氧，缺血再灌注损伤，肾移植，移植肾功能延迟，欧米加3。
摘要: Renal transplantation (RT) is considered the “gold standard” treatment for end-stage renal
disease patients. Efforts should be made to reduce ischaemia-reperfusion (IR) injury, which unavoidably
occurs in RT as long as several clinical settings, i.e. open-heart surgeries, prosthesis implantation, among
others. It is well known that IR is primarily responsible for injury associated with RT. Consequently,
tissue inflammation and organ dysfunction will ensue due to the occurrence of oxidative stress (OS) in
the reperfused tissue, a condition generated when endogenous antioxidant defences become overwhelmed
by a massive production of reactive oxygen species. Furthermore, OS is involved in the impairment
of renal function, leading to deleterious conditions such as delayed graft function (DGF), which
is a common clinical expression of IR injury in RT. Omega-3 polyunsaturated fatty acids (n -3 PUFA)
have been widely used in different clinical settings to counteract the deleterious effects of OS. Thus,
based on the currently available literature, the central aim of this review was to propose an n-3 PUFAbased
strategy targeting the key role of OS in the pathophysiology of renal IR injury in order to encourage
protection against the occurrence of DGF.
