Title:Secondary Metabolites from Cissampelos, A Possible Source for New Leads with Anti-Inflammatory Activity
Volume: 24
Issue: 16
Author(s): Mateus F. Alves, Marcus T. Scotti, Luciana Scotti*, Francisco Jaime Bezerra Mendonça, José M. B. Filho, Sílvia A. L. de Melo, Sócrates G. dos Santos and Margareth de F.F.M. Diniz
Affiliation:
- Health Sciences Center, Federal University of Paraíba, Campus I, 58051-970, João Pessoa- PB,Brazil
Keywords:
Cissampelos, anti-inflammatory activity, virtual screening, multi-target, secondary metabolites, asthma.
Abstract: The genus Cissampelos comprises of 21 species which have a wide global distribution
and various pharmacological activities such as analgesic and antipyretic, antiinflammatory,
anti-allergic, bronchodilation, and immunomodulation among others. Several
compounds, mainly alkaloids with differing biological activities have been isolated from
this genus. We will highlight antipyretic activities, anti-inflammatory, antiallergic, bronchodilatory,
and immunomodulatory activities. In addition, we applied ligand-based-virtual
screening associated with structure-based-virtual screening of a small dataset of 63 secondary
metabolites from the Cissampelos genus of an in-house data bank, in order to select
compounds with potential anti-inflammatory activity. Affinities were observed for hayatine
(26), isochondrondendrine (30), pelosine (52), sepeerine (59), and warifteine (63) to the inhibiting
enzymes MAPK p38 alpha, PKC beta, PKC theta and PKC zeta. The cissampeloflavone
compound (8) alone showed no potential inhibitory activity for PKC zeta, or affinity
for the PKC alpha. The compounds can be used as starting points for further studies on
structures with potential anti-inflammatory activity.
