摘要
背景:西方社会绿色运动的演变改变了普通人认为天然化合物本身就是无害的,比人造化学产品更为理想的态度, 目的:考虑到引进天然出血药物日益增长的兴趣,本次评估的目的是概述目前对多发性硬化(MS)病变预防和治疗的研究。 方法:通过搜索PubMed和Scopus等书目数据库,对2008年1月1日至2016年1月30日MS患者或MS动物模型进行研究,研究天然化合物在MS治疗中的有益作用。在这个更新的系统评价中,搜索术语是“多发性硬化症”或“神经变性”和“天然化合物”或“药用植物”,“传统医学”或“本地医学”)。 结果:维生素(A,B12,D,H),矿物质(硒和锂),n-3 PUFA,硫辛酸,他汀类药物,白藜芦醇,大麻,EGCG和一些益生菌的研究显示,通过预防或延缓疾病的发病。其他天然化合物如黄嘌呤,花青素,硫代葡萄糖苷,异黄酮,有机硫,类固醇糖苷和生物碱也显示出在动物模型中治疗MS的保护作用。在一些实验中也报告了不良反应。 结论:需要进一步研究重点保护天然化合物的分子机制,以减少可能的副作用,并开发新的药物。芹菜素,辣椒素,黄芩素,花青苷,黄酮苷,黄豆苷元,香豆素,萝卜硫素,蜂毒和石杉碱甲是更有前途的研究的候选者。
关键词: 替代医学,脱髓鞘,天然产物,多发性硬化,神经退行性疾病,髓鞘再生,系统综述。
Current Drug Targets
Title:Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis
Volume: 18 Issue: 13
关键词: 替代医学,脱髓鞘,天然产物,多发性硬化,神经退行性疾病,髓鞘再生,系统综述。
摘要: Background: The evolution of the Green movement in western society has changed attitudes in the general population who now perceive natural compounds as being inherently harmless and more desirable than artificial chemical products.
Objective: Considering the growing interest towards introducing naturally emerged medicines, the purpose of this review was to overview the ongoing research into prevention and treatment of multiple sclerosis (MS) lesions. Method: This review was carried out by searching bibliographic databases such as PubMed and Scopus for studies reported between 1st January 2008 to 30th January 2016 on MS patients or animal models of MS, investigating the beneficial effects of natural compounds in MS treatment. In this updated systematic review, the search terms were “multiple sclerosis” or “neurodegeneration” and (“natural compounds” or “medicinal plants”, “traditional medicine” or “native medicine”). Results: Studies with vitamins (A, B12, D, H), minerals (selenium and lithium), n-3 PUFAs, lipoic acid, statins, resveratrol, marijuana, EGCG and some probiotics have shown significant helpful effects in MS by preventing or delaying the onset of disease. Other natural compounds such as xanthines, anthocyanins, glucosinolates, isoflavones, organosulfurs, steroid glycosides, and alkaloids have also shown protective effects in the treatment of MS in animal models. Adverse effects were also reported in some of the experiments. Conclusion: Further studies with a focus on the molecular mechanisms of the protective natural compounds are needed to decrease possible side effects and to develop new medicines for MS. Apigenin, chrysin, baicalein, cyanidin, flavone glycoside, daidzein, coumestrol, sulforaphane, bee venom and huperzine A are the candidates for more prospective investigations.Export Options
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Cite this article as:
Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450118666161108124414
DOI https://dx.doi.org/10.2174/1389450118666161108124414 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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