Abstract
Background: Alzheimer's disease (AD) is the most widespread age-related neurodegenerative disease. Recently, a growing body of evidence suggested the phytochemical use to slow down AD onset and progression.
Objective: To review the phytochemical role potentially involved in AD treatment. Method: A systematic review from existing literature on phytochemicals used in the treatment of AD patients was conducted. Selection criteria included: 1) age≥60 years; 2) AD diagnosis in agreement with the criteria of National Institute on Aging-Alzheimer's Association (NIAAA), and 3) suitable measures to asses cognitive, functional and clinical status. Results: Ninety-seven articles were involved in the present study. Several phytochemicals seem to slow down AD onset, delay disease progression and let recovery through targeting multiple pathological causes by anti-cholinergic, antioxidant and anti-inflammatory features. Conclusion: Deeper knowledge on phytochemicals and their specific molecular targets is essential to guarantee safe use of these compounds as an option for AD treatment.Keywords: Phytochemicals, Alzheimer's disease, antioxidant properties, anti-inflammatory activities, acetilcholinesterase inhibitors, AChEIs.
Current Drug Targets
Title:Phytochemicals in the Treatment of Alzheimer’s Disease: A Systematic Review
Volume: 18 Issue: 13
Author(s): Grazia D'Onofrio*, Daniele Sancarlo, Qingwei Ruan, Zhuowei Yu, Francesco Panza, Antonio Daniele, Antonio Greco and Davide Seripa
Affiliation:
- Geriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Foggia,Italy
Keywords: Phytochemicals, Alzheimer's disease, antioxidant properties, anti-inflammatory activities, acetilcholinesterase inhibitors, AChEIs.
Abstract: Background: Alzheimer's disease (AD) is the most widespread age-related neurodegenerative disease. Recently, a growing body of evidence suggested the phytochemical use to slow down AD onset and progression.
Objective: To review the phytochemical role potentially involved in AD treatment. Method: A systematic review from existing literature on phytochemicals used in the treatment of AD patients was conducted. Selection criteria included: 1) age≥60 years; 2) AD diagnosis in agreement with the criteria of National Institute on Aging-Alzheimer's Association (NIAAA), and 3) suitable measures to asses cognitive, functional and clinical status. Results: Ninety-seven articles were involved in the present study. Several phytochemicals seem to slow down AD onset, delay disease progression and let recovery through targeting multiple pathological causes by anti-cholinergic, antioxidant and anti-inflammatory features. Conclusion: Deeper knowledge on phytochemicals and their specific molecular targets is essential to guarantee safe use of these compounds as an option for AD treatment.Export Options
About this article
Cite this article as:
D'Onofrio Grazia *, Sancarlo Daniele , Ruan Qingwei , Yu Zhuowei , Panza Francesco , Daniele Antonio , Greco Antonio and Seripa Davide , Phytochemicals in the Treatment of Alzheimer’s Disease: A Systematic Review, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161102121553
DOI https://dx.doi.org/10.2174/1389450117666161102121553 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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