Abstract
Background: Neurodegenerative diseases are increasingly inevitable as the population gets older, with enormous socio-economic costs. The World Health Organization (WHO) has reported that by 2040, neurodegenerative diseases will overtake cancer to become the second leading cause of death, after cardiovascular disease.
Objective: Herein, this review outlines the neuroprotective effects and clinical implications of ellagitannins, a class of hydrolysable tannins, for the management and treatment of neurodegenerative disorders. Results: Recent investigations suggest that the combination of genes and environmental toxins may contribute to the risk of developing neurodegenerative disorders. Thus, intervention strategies aimed at reducing exposure to risk factors such as life style, smoking, diet, vitamin deficiencies, chemical exposure and pollution are warranted. Modulation of dietary components including ellagitannins, as a therapeutic strategy to slow down or attenuate the progression of neuronal degeneration has become a focus of interest in the last few decades. Conclusion: Polyphenolic plant phytochemicals and ellagitannins in particular, contain an array of neuroprotective properties useful to improve human health and protect against neurodegeneration.Keywords: Antioxidant, ellagitannins, neurodegenerative, mental diseases, polyphenolic.
Current Drug Targets
Title:Neuroprotective Effects of Ellagitannins: A Brief Review
Volume: 18 Issue: 13
Author(s): Silvia Tejada, William N. Setzer, Maria Daglia, Seyed Fazel Nabavi, Antoni Sureda, Nady Braidy, Olga Gortzi and Seyed Mohammad Nabavi*
Affiliation:
- Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487,Iran
Keywords: Antioxidant, ellagitannins, neurodegenerative, mental diseases, polyphenolic.
Abstract: Background: Neurodegenerative diseases are increasingly inevitable as the population gets older, with enormous socio-economic costs. The World Health Organization (WHO) has reported that by 2040, neurodegenerative diseases will overtake cancer to become the second leading cause of death, after cardiovascular disease.
Objective: Herein, this review outlines the neuroprotective effects and clinical implications of ellagitannins, a class of hydrolysable tannins, for the management and treatment of neurodegenerative disorders. Results: Recent investigations suggest that the combination of genes and environmental toxins may contribute to the risk of developing neurodegenerative disorders. Thus, intervention strategies aimed at reducing exposure to risk factors such as life style, smoking, diet, vitamin deficiencies, chemical exposure and pollution are warranted. Modulation of dietary components including ellagitannins, as a therapeutic strategy to slow down or attenuate the progression of neuronal degeneration has become a focus of interest in the last few decades. Conclusion: Polyphenolic plant phytochemicals and ellagitannins in particular, contain an array of neuroprotective properties useful to improve human health and protect against neurodegeneration.Export Options
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Cite this article as:
Tejada Silvia, Setzer N. William, Daglia Maria, Nabavi Fazel Seyed, Sureda Antoni, Braidy Nady, Gortzi Olga and Nabavi Mohammad Seyed*, Neuroprotective Effects of Ellagitannins: A Brief Review, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161005112002
DOI https://dx.doi.org/10.2174/1389450117666161005112002 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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