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摘要
聚药理学,或两种或两种以上药物联合生产两种或两种以上不同作用位点的生物学效应表现为急性和慢性疼痛的临床管理的一个可能的治疗方法之间。神经元的机制,有助于疼痛的传播提供了许多可能的目标药物干预的复杂性和复杂性。因此,多配体具有阿片阿片或非阿片类药物作用机制是缓解疼痛的阿片类药物潜在的候选者。从这个角度来看,过去的药物化学范式”的一个目标,一种疾病”已被重新转换成”的一分子,多个目标”。多配体与鸡尾酒药物相比,除了提高镇痛效果,显示一个更可预测的药代动力学耦合到一个较小的副作用的发生率和药效学。因此,他们改善患者的依从性和降低药物相互作用的风险。在我们以前的评论多配体与阿片类药物,阿片类药物的作用机制进行了。在这里,我们处理多目标配体与阿片类药物非阿片类药物的作用机制是不同的疼痛管理潜在的候选药物。
关键词: 疼痛,阿片类,双功能,非阿片类药物,聚药理学
Current Medicinal Chemistry
Title:Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management
Volume: 23 Issue: 40
Author(s): Rita Turnaturi, Giuseppina Arico, Giuseppe Ronsisvalle, Lorella Pasquinucci, Carmela Parenti
Affiliation:
关键词: 疼痛,阿片类,双功能,非阿片类药物,聚药理学
摘要: Polypharmacology, or the associations between two or more drugs producing biological effects on two or more different sites of action could represent a possible therapeutic approach for the clinical management of acute and chronic pain. The multitude and complexity of neuronal mechanisms that contribute to pain transmission provide several possible targets for pharmacological intervention. Thus, multitarget ligands possessing opioid-opioid or non-opioid-opioid mechanisms of action are potential drug candidates for pain relief. In this perspective, the past medicinal chemistry paradigm “one-target, one-disease” has been reconsidered and converted into “one-molecule, multiple targets”. Multitarget ligands in comparison with cocktail drugs, besides an improved analgesic effect, display a more predictable pharmacokinetic and pharmacodynamic profile coupled to a less incidence of side-effects. Thus, they ameliorate patient compliance and decrease the risk of drug-drug interactions. In our previous review multitarget ligands with an opioid-opioid mechanism of action were described. Here, we deal with multitarget ligands with opioid-non opioid mechanism of action as potential drug candidates for the management of different pain states.
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Rita Turnaturi, Giuseppina Arico, Giuseppe Ronsisvalle, Lorella Pasquinucci, Carmela Parenti , Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management, Current Medicinal Chemistry 2016; 23 (40) . https://dx.doi.org/10.2174/0929867323666161024151734
DOI https://dx.doi.org/10.2174/0929867323666161024151734 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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