Title:An Updated Review of ISCOMSTM and ISCOMATRIXTM Vaccines
Volume: 22
Issue: 41
Author(s): Alexis Garcia and Diego Lema
Affiliation:
Keywords:
ISCOMs, ISCOMATRIX™, vaccine, adjuvant, safety, immunogenicity, immune response, innate immune response, adaptive
immune response.
Abstract: The need for the improvement of vaccine potency as well as reducing toxicity in
healthy recipients has motivated studies of the formulation of vaccines regarding control of
how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues
following vaccine administration. Immunostimulatory complexes (ISCOMs) and ISCOMATRIXTM
adjuvants are versatile and flexible systems with various phospholipids and saponin
components. They are being used in novel vaccines for either infectious diseases or cancer.
This article presents a brief review of the latest developments using such adjuvants and possible
new applications.