Title:Subcutaneous Immunoglobulins: A Promising Alternative for Immunomodulation?
Volume: 22
Issue: 41
Author(s): Silvia Sanchez-Ramon, Angel L. Corbi, Agueda Garcia Fidalgo and Angeles Dominguez-Soto
Affiliation:
Keywords:
Subcutaneous immunoglobulin, immunomodulation, mechanisms of action.
Abstract: Cumulative recent evidence from clinical trials, observational studies and case
reports has shown that subcutaneous administration of immunoglobulin (SCIg) exerts similar
immunomodulatory capacity than intravenous immunoglobulin (IVIg) in autoimmune
neurological diseases. Besides the beneficial clinical effects, the profile of safety and autonomy
for the patient is higher for SCIg, while it is cost-saving in terms of the health resources
used. However, there are still very few approved indications for SCIg and a certain resistance
to choose SCIg for other autoimmune conditions even despite patients’ interests. Here
we present an updated review of the known immunomodulatory mechanisms of action of Ig
and the current hypothesis supporting the clinical and immunological advantages of SCIg
over IVIg that derive from their specific pharmacokinetic features.
