Title:Genetic Influences in Cannabis Use Disorder and Psychosis: Dopamine and Beyond
Volume: 22
Issue: 42
Author(s): Amine Benyamina, Laurent Karila, Geneviève Lafaye and Lisa Blecha
Affiliation:
Keywords:
Cannabis use disorder, psychosis, COMT, CNR1, GWAS.
Abstract: Cannabis consumption has radically changed over the last several decades. Tetrahydrcannbidiol
concentrations are rising, cannabidiol concentrations falling and cannabis is
becoming legalized in several regions of the globe. Concerns have been raised as to the
impact of increased cannabis exposure within the general population on public health. One
of the more serious concerns is the potential relationship between cannabis consumption and
psychosis. Research has shown a relationship between increasing cannabis use and increasing
psychosis risk. This risk is moderated by other factors such as stress and a family history
of psychosis. Within this context, it is important to determine potential markers for future
psychosis risk. Genetic and epigenetic research in cannabis and psychosis is in its early
stages. One common denominator between cannabis use disorder and psychosis is dopamine
dysfunction. Research has begun to link heightened dopamine reactivity with the psychotomimetic
effects of cannabis. Studies in COMT and DRD2 polymorphisms have failed to
show greater associations with transition to psychosis. Studies of AKT1 have shown slightly more promising
results. Genome-wide association studies have recently been published some indicating novel polymorphisms.
These may pave the way to alternate hypotheses to explain the missing links between cannabis use and increased
risk of psychosis. Such knowledge may eventually lead to new pharmacotherapies in addition to the means of
screening patients for psychosis risk.
