Title:Inflammation: A Multidimensional Insight on Natural Anti-Inflammatory Therapeutic Compounds
Volume: 23
Issue: 33
Author(s): Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Akbar Masood, Mohammad Afzal Zargar, Showkat Ahmad Ganie
Affiliation:
关键词:
自由基；炎症；标记物； 癌症；药物成分；炎症通路。
摘要: Derailed inflammation causes severe damage to the normal tissues
resulting in various pathological conditions such as auto-inflammatory disorders,
neurodegenerative diseases and cancer. Cure of inflammatory diseases
is a big challenge. Medicinal herbs used traditionally represent the best option
for obtaining effective anti-inflammatory therapeutics. Present review
provides a thorough insight about various pathways, consequences and
therapeutic strategies of inflammation with prime focus to expose indigenous
anti-inflammatory herbal compounds along with their structures and diverse
range of mechanisms of action. Over hundred medicinal plants with scientifically
reported anti-inflammatory properties were reviewed. Different parts
of the plants like roots, stem, bark, leaves, flowers and seeds contain active compounds with
potential anti-inflammatory properties. Such compounds act at multiple targets in the inflammatory
response pathways and regulate multitude of chemical mediators, enzymes,
genes or cellular functions to alleviate inflammation. Although a large number of antiinflammatory
herbal compounds have been isolated but the mechanism of action of bulk of
compounds has not been elucidated comprehensively. Besides there is need for conducting
well designed clinical trials so that the promising compounds could be used as effective antiinflammatory
therapeutic agents in future.
