Title:Protective Effect of Perindopril on Tumor Progression and Angiogenesis in Animal Model of Breast Cancer
Volume: 17
Issue: 7
Author(s): Snehal S. Patel*Surender Nakka
Affiliation:
- Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, 382 481,India
Keywords:
Angiogenesis, angiotensin converting enzyme inhibitors, breast cancer, perindopril, tumor progression.
Abstract: Background: Studies have shown that the renin angiotensin system via angiogenesis is involved in
tumor development.
Objective: Therefore, objective of the present study was to examine the effect of perindopril on tumor growth and
angiogenesis in animal models of breast cancer.
Methods: In the present study, the effect of perindopril on tumor development of mammary gland cancer induced
by 7,12-dimethylbenz[a]anthracene, mouse tumor xenograft and corneal micropocket model has been
investigated. Anti-angiogenic effect by chick yolk sac membrane assay has also been studied.
Results: In the present study, it has been found that perindopril produced a significant inhibition of tumor growth,
in DMBA induced breast cancer. Treatment also produced significant suppression of cancer biomarkers such as
lactate dehydrogenase, gamma glutamyl transferase and inflammatory markers such as C-reactive protein,
erythrocyte sedimentation rate. Histopathological analysis also showed that perindopril was able to inhibit tumor
development by the inhibition of hyperplastic lesions. Perindopril produced significant inhibition of tumor
growth, in a mouse xenograft model and caused inhibition of neovascularization in the corneal micropocket
model. In chick yolk sac membrane assay, perindopril showed inhibition of vascular growth and reduced blood
vessel formation.
Conclusion: Therefore, perindopril is widely used in clinical practice, may represent a neo-adjuvant therapy for
treatment of breast cancer.
