Abstract
Alcoholic Liver Disease (ALD) represents the second most common indication for Liver Transplantation (LT) worldwide. Outcomes of LT for ALD are comparable with those of liver transplantation for other aetiologies of liver disease; however, it's still considered a controversial indication to LT, mainly because ALD is considered a self inflicted disease, and for the risk of relapse after LT. Most transplant programs require 6 months of abstinence in order to consider a patient suitable for LT, however the role of the length of pre transplant abstinence as predictor of alcohol relapse after LT is still controversial. A psycho-social assessment to establish the likelihood of long-term abstinence after LT should be performed in patients with ALD potential candidates for LT. Acute alcoholic hepatitis is considered a contraindication to transplantation in most transplant centers. However, early LT, in selected patients, with a first episode of severe alcoholic hepatitis not responding to medical therapy, has been shown to improve survival. Further studies are needed to better assess the risk of alcohol relapse after LT in patients with acute alcoholic hepatitis.
Keywords: Alcohol, cirrhosis, acute alcolich hepatitis liver Transplantation.
Reviews on Recent Clinical Trials
Title:Orthotopic Liver Transplantation in Alcoholic Liver Disease Patients
Volume: 11 Issue: 3
Author(s): Giacomo Germani, Alberto Zanetto, Alberto Ferrarese, Francesco P. Russo, Marco Senzolo and Patrizia Burra
Affiliation:
Keywords: Alcohol, cirrhosis, acute alcolich hepatitis liver Transplantation.
Abstract: Alcoholic Liver Disease (ALD) represents the second most common indication for Liver Transplantation (LT) worldwide. Outcomes of LT for ALD are comparable with those of liver transplantation for other aetiologies of liver disease; however, it's still considered a controversial indication to LT, mainly because ALD is considered a self inflicted disease, and for the risk of relapse after LT. Most transplant programs require 6 months of abstinence in order to consider a patient suitable for LT, however the role of the length of pre transplant abstinence as predictor of alcohol relapse after LT is still controversial. A psycho-social assessment to establish the likelihood of long-term abstinence after LT should be performed in patients with ALD potential candidates for LT. Acute alcoholic hepatitis is considered a contraindication to transplantation in most transplant centers. However, early LT, in selected patients, with a first episode of severe alcoholic hepatitis not responding to medical therapy, has been shown to improve survival. Further studies are needed to better assess the risk of alcohol relapse after LT in patients with acute alcoholic hepatitis.
Export Options
About this article
Cite this article as:
Germani Giacomo, Zanetto Alberto, Ferrarese Alberto, Russo P. Francesco, Senzolo Marco and Burra Patrizia, Orthotopic Liver Transplantation in Alcoholic Liver Disease Patients, Reviews on Recent Clinical Trials 2016; 11 (3) . https://dx.doi.org/10.2174/1574887111666160815102228
DOI https://dx.doi.org/10.2174/1574887111666160815102228 |
Print ISSN 1574-8871 |
Publisher Name Bentham Science Publisher |
Online ISSN 1876-1038 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Ghrelin and Cardiovascular Diseases
Current Cardiology Reviews Energizing Genetics and Epi-genetics: Role in the Regulation of Mitochondrial Function
Current Genomics Preventing and Treating Anthracycline-Related Cardiotoxicity in Survivors of Childhood Cancer
Current Cancer Therapy Reviews Hsp70 Protein Complexes as Drug Targets
Current Pharmaceutical Design Eisenmenger Syndrome: Recent Advances in Pharmacotherapy
Cardiovascular & Hematological Agents in Medicinal Chemistry MDMA Toxicity and Pathological Consequences: A Review About Experimental Data and Autopsy Findings
Current Pharmaceutical Biotechnology Editorial (Thematic Issue: Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Development (Part B))
Current Pharmaceutical Design Late-Onset Glycogen Storage Disease Type 2
Current Molecular Medicine Dietary Carbohydrates that Modulate the Immune System
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Selenium in the Prevention and Treatment of Hepatocellular Carcinoma
Anti-Cancer Agents in Medicinal Chemistry The Tree of Sirtuins and the Garden of Cardiovascular Youth
Current Vascular Pharmacology Protein Synthesis and Assembly in Mitochondrial Disorders
Current Topics in Medicinal Chemistry A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure
Current Pharmaceutical Design Study of Prolactin Permeation Through the Pericardium and Its Bioavailability
Protein & Peptide Letters Omega-3 Fatty Acids: Role in Metabolism and Cardiovascular Disease
Current Pharmaceutical Design Patient-Specific Induced Pluripotent Stem Cell Models in Mitochondrial Diseases
Current Stem Cell Research & Therapy Current Therapeutic Concepts in Peripartum Cardiomyopathy
Current Pharmaceutical Design CD36 and Intestinal Fatty Acid Absorption
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Statins and Cardiovascular Diseases: From Cholesterol Lowering to Pleiotropy
Current Pharmaceutical Design Editorial [Hot Topic:Applications of Angiotensin Converting Enzyme Inhibitors and of Angiotensin II Receptor Blockers in Pharmacology and Therapy: An Update (Executive Editor: Agostino Molteni)]
Current Pharmaceutical Design