Title:Early Docetaxel and Androgen Deprivation in the Treatment of Metastatic, Hormone-sensitive Prostate Cancer
Volume: 11
Issue: 4
Author(s): Davide Tassinari, Emiliano Tamburini, Lorenzo Gianni, Fabrizio Drudi, Manuela Fantini, Carlotta Santelmo, Lucia Stocchi, Francesco Montanari and Sergio Sartori
Affiliation:
Keywords:
Docetaxel, chemotherapy, prostate cancer, hormone-sensitive disease.
Abstract: Background: To assess the role of docetaxel plus androgen deprivation in metastatic, hormone-
sensitive prostate cancer.
Methods: A qualitative systematic review of literature was performed. All the randomized phase III trials
comparing docetaxel plus androgen deprivation with androgen deprivation alone in patients with
metastatic, hormone-sensitive prostate cancer were considered eligible and included into the analysis.
Results: Six papers (3 randomized clinical trials, and 3 systematic reviews with meta-analysis) were
considered eligible and included into the analysis. A significant improvement in time to progression and
OS in the entire population treated with docetaxel plus androgen deprivation was reported in all the trials
and meta-analyses, and in two trials and all meta-analyses, respectively. One trial reported improvement
of OS only in patients with high volume disease, and the meta-analysis that also analyzed the
subgroups of patients with high or low volume disease reported a benefit of docetaxel plus androgen
deprivation for either the entire population or the two subgroups of patients.
Conclusion: The early use of docetaxel combined with androgen deprivation improves the main outcomes
in the treatment of metastatic, hormone-sensitive prostate cancer. The available data suggest that
docetaxel plus androgen deprivation could be considered the novel standard for fit patients with metastatic,
hormone-sensitive prostate cancer.
