Title:Nanomedicine for Intra-Articular Drug Delivery in Rheumatoid Arthritis
Volume: 23
Issue: 23
Author(s): Hannah O'Mary, Inmaculada del Rincόn, Zhengrong Cui
Affiliation:
关键词:
抗关节炎药物；慢性炎症；通过渗漏血管外渗；发炎的关节；纳米粒子；单克隆抗体；siRNA。
摘要: Rheumatoid arthritis is characterized by chronic inflammation within the joint. Recent
developments in the understanding of inflammation have led to an increased interest in the use of
nanomedicine in the treatment and diagnosis of rheumatoid arthritis. The ability of nanomedicine,
such as nanoparticles, to permeate into and/or retain within the inflamed joint after intravenous
and/or intra-articular administration has proven to be beneficial in improving rheumatoid arthritis
therapy while reducing systemic exposure of patients to potentially toxic anti-arthritic drugs. This
review aims at explaining the major applications of nanomedicine in rheumatoid arthritis treatment
and diagnosis.
