Title:Adamantane – A Lead Structure for Drugs in Clinical Practice
Volume: 23
Issue: 29
Author(s): Katarina Spilovska, Filip Zemek, Jan Korabecny, Eugenie Nepovimova, Ondrej Soukup, Manfred Windisch, Kamil Kuca
Affiliation:
关键词:
Adamantane
摘要: The adamantane moiety is the structural backbone of numerous
compounds and its discovery launched a new field of chemistry studying the
approaches to the synthesis as well as the physicochemical and biological
properties of organic polyhedral compounds with practical application in the
pharmaceutical industry. Adamantane derivatives have proven to be very potent
compounds in a wide range of applications from systemic to topical therapy. This
review summarizes the currently available adamantane derivatives in clinical
practice (amantadine, memantine, rimantadine, tromantadine, adapalene,
saxagliptin, vildagliptin), focusing on mechanisms of action, pharmacokinetics,
pharmacodynamics and clinical trials. The adamantane-based compounds
presented in this manuscript have been approved for a wide spectrum of
indications (antivirals, antidiabetics and against Alzheimer’s and Parkinson’s
disease). Each of the compounds proved to be of vital importance in their
therapeutic indication for numerous patients worldwide. This review also
considers the mechanisms of side effects to deliver a complete perspective on
current treatment options.
