Title:Non-Demented Individuals with Alzheimer’s Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies
Volume: 22
Issue: 26
Author(s): Olga Zolochevska and Giulio Taglialatela
Affiliation:
Keywords:
Alzheimer’s disease, Non-Demented with Alzheimer’s Neuropathology, compensatory mechanisms in AD, resistance to cognitive
decline.
Abstract: Alzheimer’s disease (AD) is a terminal neurodegenerative disorder that is characterized
by accumulation of amyloid plaques and neurofibrillary tangles in the central
nervous system. However, certain individuals remain cognitively intact despite manifestation
of substantial plaques and tangles consistent with what would be normally associated
with fully symptomatic AD. Mechanisms that allow these subjects to escape dementia remain
unresolved and understanding such protective biological processes could reveal novel
targets for the development of effective treatments for AD. In this review article we discuss
potential compensatory mechanisms that allow these individuals to remain cognitively intact
despite the typical AD neuropathology.
