Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Antiarrhythmic Mexiletine: A Review on Synthetic Routes to Racemic and Homochiral Mexiletine and its Enantioseparation

Author(s): Alessia Catalano and Alessia Carocci

Volume 23, Issue 29, 2016

Page: [3227 - 3244] Pages: 18

DOI: 10.2174/0929867323666160517120234

Price: $65

conference banner
Abstract

Mexiletine is an oral class IB antiarrhythmic agent. Although it was primarily studied for the treatment of ventricular arrhythmias, it has been demonstrated to be useful also for the treatment of chronic painful diabetic neuropathy, neuropathic pain, skeletal muscle channelopathies, and recently amyotrophic lateral sclerosis. This review presents a detailed report on the different synthetic routes to racemic and homochiral mexiletine developed in the last decades, as well as analytical studies regarding enantioseparation methods and enantiomeric excess determination. Finally, some analogues of mexiletine reported in the literature, most of which along with pharmacological studies, have been mentioned.

Keywords: Antiarrhythmic agents, Antimyotonic agents, Mexiletine, Mexiletine analogues, Phasic block, Sodium channel blockers.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy