Title:Impact of Macrophages in Atherosclerosis
Volume: 23
Issue: 18
Author(s): Xinjie Lu
Affiliation:
关键词:
动脉粥样硬化，先天免疫，Toll样受体，巨噬细胞，巨噬细胞极化，氧化低密度脂蛋白。
摘要: Atherosclerosis is driven by inflammation, with a strong
involvement of innate immunity, and involves an expansion of the arterial
intima, a normally small area composed of several cell types including
smooth muscle cells, lipids, monocytes, macrophages, dendritic cells, and
extracellular matrix. Macrophages derived from recruited monocytes are
predominant innate immune cells that play crucial roles in the formation of
atherosclerotic lesions. Human atherosclerotic plaques have shown that
macrophage subsets within a plaque might be more useful for explaining
plaque phenotype than just simply giving the total number of
macrophages. Therefore, recognizing the roles of macrophage subsets in
atherosclerotic plaque formation, progression, and regression would be most helpful for
identification of novel strategies to stabilize, or attenuate atherosclerotic lesions. This review
discusses the impact of macrophage subsets and their roles in atherosclerosis.
