Abstract
As the ever more critical role of individualized therapy in the cancer treatment and management, circulating tumor cells (CTCs) have caught much attention for providing a promising way in metastases establishment, disease diagnosis and prognosis. Also, their presence has been generally considered as the rationale behind the application of systemic adjuvant chemotherapy. Therefore, CTCs open a new window for the clinical utility, especially for the diagnosis and evaluation of cancer, and move toward personalized medicine. In this review, we summarize the pros and cons of current available technologies for enrichment and detection of CTCs comprehensively. In addition, recent advances in the development of microfluidic and nanotechnology for isolation of CTCs are outlined. Furthermore, circulating tumor microemboli (CTM)-based and telomerase-based assays, the emerging methods for CTC detection and the application of CTCs in the clinic, have also been evaluated. Finally, perspectives and challenges of all these methods in the field of CTCs’ isolation and detection are presented.
Keywords: Circulating tumor cells, disseminated tumor cells, enrichment, detection, circulating tumor microemboli, pros and cons, personalized medicine.
Anti-Cancer Agents in Medicinal Chemistry
Title:Circulating Tumor Cells: A New Window for Diagnosis and Evaluation of Cancer
Volume: 16 Issue: 12
Author(s): Meihui Liu, Min Tang, Ming Li, Feng Gao, Can Shi, Jing Hou and Wenbin Zeng
Affiliation:
Keywords: Circulating tumor cells, disseminated tumor cells, enrichment, detection, circulating tumor microemboli, pros and cons, personalized medicine.
Abstract: As the ever more critical role of individualized therapy in the cancer treatment and management, circulating tumor cells (CTCs) have caught much attention for providing a promising way in metastases establishment, disease diagnosis and prognosis. Also, their presence has been generally considered as the rationale behind the application of systemic adjuvant chemotherapy. Therefore, CTCs open a new window for the clinical utility, especially for the diagnosis and evaluation of cancer, and move toward personalized medicine. In this review, we summarize the pros and cons of current available technologies for enrichment and detection of CTCs comprehensively. In addition, recent advances in the development of microfluidic and nanotechnology for isolation of CTCs are outlined. Furthermore, circulating tumor microemboli (CTM)-based and telomerase-based assays, the emerging methods for CTC detection and the application of CTCs in the clinic, have also been evaluated. Finally, perspectives and challenges of all these methods in the field of CTCs’ isolation and detection are presented.
Export Options
About this article
Cite this article as:
Liu Meihui, Tang Min, Li Ming, Gao Feng, Shi Can, Hou Jing and Zeng Wenbin, Circulating Tumor Cells: A New Window for Diagnosis and Evaluation of Cancer, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (12) . https://dx.doi.org/10.2174/1871520616666160223113743
DOI https://dx.doi.org/10.2174/1871520616666160223113743 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Discovery of Lead compounds targeting transcriptional regulation
Transcriptional regulation plays key physiological functions in body growth and development. Transcriptional dysregulation is one of important biomarkers of tumor genesis and progression, which is involved in regulating tumor cell processes such as cell proliferation, differentiation, and apoptosis. Additionally, it plays a pivotal role in angiogenesis and promotes tumor metastasis ...read more
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Innovative targets in medicinal chemistry
Medicinal chemistry continuously evolves in response to emerging healthcare needs and advancements in scientific understanding. This special issue explores the current landscape of innovative targets in medicinal chemistry, highlighting the quest for novel therapeutic avenues. From traditional drug targets such as enzymes and receptors to emerging targets like protein-protein interactions ...read more
Rechallenge Therapy in different types of cancer
Cancer is responsible for approximately 8 million deaths annually all worldwide. The Global burden of cancer (GLOBOCAN) 2020 reported 19.3 million new cases of cancer, which is projected to increase to 28.4 million by 2040.In the future , female breast cancer will be the most common cancer (11.7%) followed by ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Emerging Features in the Regulation of MMP-9 Gene Expression for the Development of Novel Molecular Targets and Therapeutic Strategies
Current Drug Targets - Inflammation & Allergy Mevalonate Cascade and Small Rho GTPase in Spinal Cord Injury
Current Molecular Pharmacology Development of Cisplatin Nanoparticles as Dry Powder Inhalers for Lung Cancer
Current Nanoscience Immunotherapy with Tumor Vaccines for the Treatment of Malignant Gliomas
Current Drug Discovery Technologies Cancer Microbiome; Opportunities and Challenges
Endocrine, Metabolic & Immune Disorders - Drug Targets Postoperative Radiotherapy After Radical Prostatectomy: Adjuvant or Salvage?
Current Cancer Therapy Reviews A Prospective Study of the Clinical and Demographic Profile of Type 2 Diabetes Mellitus Patients Receiving Antidiabetic Drug Combinations
Current Diabetes Reviews Tubulin Colchicine Binding Site Inhibitors as Vascular Disrupting Agents in Clinical Developments
Current Medicinal Chemistry Targeted Liposomal Drug Delivery in Cancer
Current Pharmaceutical Design The Role of Chronic Periodontitis in Prevention and Treatment of Head and Neck Cancers
Current Cancer Therapy Reviews RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy
Current Topics in Medicinal Chemistry Acute Renal Failure in Different Malignant Tumors
Current Medicinal Chemistry Current and Potential Use of Citrus Essential Oils
Current Organic Chemistry Exploring the Potential of NO-Independent Stimulators and Activators of Soluble Guanylate Cyclase for the Medical Treatment of Erectile Dysfunction
Current Pharmaceutical Design HUHS1015 Induces Necroptosis and Caspase-Independent Apoptosis of MKN28 Human Gastric Cancer Cells in Association with AMID Accumulation in the Nucleus
Anti-Cancer Agents in Medicinal Chemistry The Complexities of TGF-β Action During Mammary and Squamous Cell Carcinogenesis
Current Pharmaceutical Biotechnology Targeting Telomerase by Antisense-Based Approaches: Perspectives for New Anti-Cancer Therapies
Current Pharmaceutical Design Modulation of P2 Receptors on Pancreatic β-cells by Agonists and Antagonists: A Molecular Target for Type 2 Diabetes Treatment
Current Diabetes Reviews Emerging Immunotargets in Bladder Cancer
Current Drug Targets Targeting Platinum Resistant Disease in Ovarian Cancer
Current Medicinal Chemistry