Abstract
Polymersomes are self-assembled nano-vesicles composed of amphiphilic block copolymers. These building blocks can be selected from a large number of hydrophilic and hydrophobic polymers in order to achieve required properties of the final system, such as biodegradability, sustainable and multiple stimuli-response drug release, long blood circulation, and low toxicity. Moreover, the surface of polymersomes can be functionalized to induce targeting character. Polymersomes are able to encapsulate a broad range of hydrophilic or/and hydrophobic molecules either in the aqueous core or membrane bilayer, respectively. In addition, colloidal stability and low membrane fluidity make polymersomes attractive nano-sized drug carriers. The review describes polymersomes compositions, their applications in pharmaceutical delivery, and preparation methods.
Keywords: Polymersomes, amphiphilic block copolymers, pharmaceutical delivery, hydrophobic drugs, hydrophilic drugs, co-loading, preparation methods.
Current Pharmaceutical Design
Title:Nanoscale Polymersomes as Anti-Cancer Drug Carriers Applied for Pharmaceutical Delivery
Volume: 22 Issue: 19
Author(s): Ruslan G. Tuguntaev, Chukwunweike Ikechukwu Okeke, Jing Xu, Chan Li, Paul C. Wang and Xing-Jie Liang
Affiliation:
Keywords: Polymersomes, amphiphilic block copolymers, pharmaceutical delivery, hydrophobic drugs, hydrophilic drugs, co-loading, preparation methods.
Abstract: Polymersomes are self-assembled nano-vesicles composed of amphiphilic block copolymers. These building blocks can be selected from a large number of hydrophilic and hydrophobic polymers in order to achieve required properties of the final system, such as biodegradability, sustainable and multiple stimuli-response drug release, long blood circulation, and low toxicity. Moreover, the surface of polymersomes can be functionalized to induce targeting character. Polymersomes are able to encapsulate a broad range of hydrophilic or/and hydrophobic molecules either in the aqueous core or membrane bilayer, respectively. In addition, colloidal stability and low membrane fluidity make polymersomes attractive nano-sized drug carriers. The review describes polymersomes compositions, their applications in pharmaceutical delivery, and preparation methods.
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Cite this article as:
Tuguntaev G. Ruslan, Okeke Ikechukwu Chukwunweike, Xu Jing, Li Chan, Wang C. Paul and Liang Xing-Jie, Nanoscale Polymersomes as Anti-Cancer Drug Carriers Applied for Pharmaceutical Delivery, Current Pharmaceutical Design 2016; 22 (19) . https://dx.doi.org/10.2174/1381612822666160217142319
DOI https://dx.doi.org/10.2174/1381612822666160217142319 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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