Title:Polymer Particulates in Drug Delivery
Volume: 22
Issue: 19
Author(s): Harmeet Kaur, Virender Kumar, Krishan Kumar, Sandeep Rathor, Parveen Kumari and Jasbir Singh
Affiliation:
Keywords:
Microparticles, Nanoparticles, Polymeric, Micelles, Drug release, Targeting, Factors, Biomolecules, Dendrimers, Conjugation,
Stimuli-responsive.
Abstract: Development of effective drug delivery systems is important for medicine and healthcare. Polymer particulates
(micro- and nanoparticles) have opened new opportunities in the field of drug delivery by overcoming
various limitations of conventional delivery methods. The properties of polymeric particles can be readily tuned by
precisely engineering the constituent blocks of polymers for improving drug loading, release rate, pharmacokinetics,
targeting, etc. The end-groups of various polymers can be readily modified with ligands making them suitable
for recognizing by cell-specific receptors, providing cellular specificity, and superior intracellular delivery. This
review will mainly cover delivery of many potential drugs and biomolecules by means of polymeric microparticles,
nanoparticles and copolymer micelles or assemblies. An overview about formulation methods of polymer particulates
has also been addressed. Attempt has been made to cover all the potential polymers that are well known in
pharmaceutical history.
