Title:Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel
Volume: 16
Issue: 7
Author(s): Jianwei Li, Anping Li, Minghua Li, Yufeng Qiao and Hui Zhang
Affiliation:
Keywords:
Larotaxel, taxanes, synthesis, MCF-7, cytotoxicity, breast cancer.
Abstract: Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a
commercial material and their structures were characterized using NMR and MS spectral data. The cytotoxicity of
two metabolites was performed on breast cancer cell lines MCF-7, MX-1 and MDA-MB-231. It is remarkable that
both of these two desired taxanes showed great potent cytotoxic effect.
