Title:Pharmacological Drug Delivery Strategies for Improved Therapeutic Effects: Recent Advances
Volume: 22
Issue: 11
Author(s): Reema Savaliya, Poornima Singh and Sanjay Singh
Affiliation:
Keywords:
Drug delivery, cancer nanotechnology, nanomaterials, siRNA silencing, cell penetrating peptides.
Abstract: The latest pharmacologic research has resulted number of new molecules with the potential to modernize
the prevention or treatment of different complex diseases, including cancer. The therapeutics generally include
moieties such as proteins, drugs and genes, etc. Current activities in the pharmacological field include the development
of novel drug-delivery systems to overcome pharmacokinetic glitches such as limited bioavailability, unwanted
distribution, drug resistant, and stability, etc. Therefore, to address these issues various biotechnological
and pharmacological techniques has been introduced. However, effective drug delivery with improved efficacy remains
challenging. This review is focused towards different strategies such as physical and biological methods for
efficacious delivery at desired tissues and even sub-cellular targeting. Emphasis is also given about nanotechnology
based drug or gene delivery strategies and co-delivery of drug-drug; gene-gene or combinations of drug-gene, etc. are the current cuttingedge
methods, which are under clinical or pre-clinical stage of research. Uses of biodegradable materials, such as liposomes and polymeric
particles are another class of drug delivery vehicles, which have shown tremendous success, are also discussed. Towards the end, future
directions of pharmacological drug delivery methods have also been summarized.
