Title:Pharmacokinetics and Systemic Activity of a New Patent of an Inhaled Corticosteroid/Long-Acting β2-Agonist Combination for Use in Asthma Therapy: Fluticasone Furoate/Vilanterol Trifenatate
Volume: 9
Issue: 2
Author(s): Ole D. Wolthers
Affiliation:
Keywords:
Area under the curve, asthma, bioavailability, fluticasone fumarate, fluticasone fumarate/vilanterol trifenatate,
hypothalamic-pituitary-adrenal function, inhaled corticosteroids, long-acting β2-agonist, pharmacokinetics, systemic activity,
urine cortisol, vilanterol trifenatate.
Abstract: The present paper reviews pharmacokinetics and systemic activity of a new patent of fluticasone
fumarate/vilanterol trifenatate and summarises the efficacy data in children, adolescents and
adults with asthma. Bioavailability of oral deposition of fluticasone furoate is approximately 1%, of
oral and pulmonary deposition 15%. Fluticasone furoate 400, 600 and 800µg have been associated
with reductions in 24h urine cortisol excretion in adults, whereas several studies on fluticasone furoate/
vilanterol trifenatate 100/25µg and 200/25µg once daily found no suppressive effects. Bronchodilation
was detected in adults with asthma from 5 minutes after vilanterol trifenatate was inhaled and up to 24 hours
after. Five large clinical trials which were sponsored by the manufacturer GlaxoSmithKline provided evidence that dry
powder fluticasone furoate/vilanterol trifenatate 100/25µg and 200/25µg once daily are efficacious in asthma in patients ≥
12 years of age. It remains to be proven, however, that once daily dosing may improve asthma control as compared to
twice daily dosing. Efficacy and the systemic activity potential for hypothalamic-pituitary-adrenal and growth suppression
of fluticasone furoate have not been established in children. The potential for systemic acitivity of fluticasone furoate in
children may be assessed by knemometry.
