Title:Phosphodiesterase 4 (PDE4) Inhibitors in the Treatment of COPD: Promising Drug Candidates and Future Directions
Volume: 23
Issue: 2
Author(s): Naisargee Parikh and Asit K. Chakraborti
Affiliation:
关键词:
哮喘，西洛，COPD，PDE4抑制剂通路，磷酸二酯酶，罗氟司特。
摘要: The PDE4 enzyme has been proven to be a versatile drug target for therapeutics
to treat diverse disease conditions such as asthma, COPD, diabetes, Huntington’s disease,
and various other inflammatory disorders. The treatment of COPD is the most studied utility
for PDE4 inhibitors due to their ability to inhibit inflammatory cell responses. Roflumilast is
the only approved drug belonging to this class to treat COPD and has shown significant results
in the treatment of asthmatic patients. This perspective highlights the pharmacological
details of roflumilast and cilomilast. Moreover, efforts have been made to justify the superiority of roflumilast
over cilomilast by detailed comparison of their pharmacological, pharmacokinetic, pharmacodynamic properties
and structural features. Several other molecules, with promising PDE4 inhibitory activity have also been
highlighted. Commonly associated side effects with this class of compounds, their management, and future direction
towards the development of PDE4 inhibitors with improved therapeutic index are the focus of this
perspective. More emphasis has been given towards the future development strategies to limit the side effects
such as emesis and to achieve better benefit to risk ratio.
