Title:Potential of Natural Products of Herbal Origin as Monoamine Oxidase Inhibitors
Volume: 22
Issue: 3
Author(s): Ilkay Erdogan Orhan
Affiliation:
Keywords:
Monoamine oxidase, enzyme inhibition, natural compounds, MAO, flavonoid, alkaloid, coumarin.
Abstract: Monoamine oxidase (MAO, E.C. 1.4.3.4) is a flavin-adenine type of enzyme with two isoforms referred
to MAO-A and MAO-B that function for oxidation of monoamines. While MAO-A inhibitors are effective as antidepressant
and anxiolytic drugs (e.g. chlorgyline, moclobemide, and lazabemide), inhibitors of MAO-B (e.g. Ldeprenyl,
pargyline, and rasagiline) are used against neurodegenerative diseases such as Parkinson’s and Alzheimer’s
diseases. Considering the need for novel MAO inhibitors due to side effects of the current ones, natural
products have become attractive targets for researchers. Up till now, many studies revealed strong MAO inhibitory
activity of flavonoid, xanthone, alkaloid, and coumarin derivatives from herbal sources, which also become good
models for the synthetic MAO inhibitors. For this purpose, the present review focuses on examples of in vitro and
in vivo MAO-inhibiting natural compounds of plant origin from a wide variety of chemical classes isolated mainly
between 2000 – 2015.