Title:Leuckart Synthesis and Pharmacological Assessment of Novel Acetamide Derivatives
Volume: 16
Issue: 7
Author(s): Priyanka Rani, Dilipkumar Pal, Rahul Rama Hegde and Syed Riaz Hashim
Affiliation:
Keywords:
Anti-inflammatory, anti cancer, analgesic, anti pyretic, phenoxyacetamide.
Abstract: A new concatenation of N-(1-(4-bromophenyl)ethyl)-2-phenoxyacetamide and N-(1-(4-methoxyphenyl)
ethyl)-2-phenoxyacetamide derivatives having 2-phenoxy-N-(1-phenylethyl)acetamide nucleus as common in both
the types was synthesized for the sake of achieve titled compounds as potential cytotoxic, anti-inflammatory,
analgesic and antipyretic agents. All the novel derivatives have been synthesized through multi-step reaction
sequence starting from Leuckart reaction. The structural assignments of the new compounds have been determined
by virtue of their IR, 1H NMR, 13C NMR, elemental analysis and mass spectrum analysis. All the synthesized compounds were assessed
for cytotoxicity and anti-inflammatory, analgesic and antipyretic effects. Among the series, compounds 3a, 3c, 3g and 3h possess
cytotoxic, anti-inflammatory, analgesic and antipyretic activities comparable with standard drugs. The synthesized compounds were
found to be active because of the presence of bromo, tert- butyl and nitro groups at position 4 of phenoxy nucleus.
