Title:Hepato and Cardiotoxicity of Chemotherapeutic Treatment Evaluated by Means of Small Animal Imaging
Volume: 17
Issue: 3
Author(s): Fiorella Carla Tesan, Mariano Gaston Portillo, Diego Martinel-Lamas, Vanina Araceli Medina, Maria Jimena Salgueiro and Marcela Beatriz Zubillaga
Affiliation:
Keywords:
Doxorubicin, cardiotoxicity, hepatotoxicity, small animal imaging, 99mTc-phytate, 99mTc-disida, 99mTc-sestamibi.
Abstract: Background: Chemotherapy is one of the most common approaches for cancer treatment. Particularly
Doxorubicin has been proven to be effective in the treatment of many soft and solid tumors for locally advanced and
metastatic cancer. It is not easy to clinically evaluate the chemotoxic or chemoprotective effect of some drugs, even
more when there is a subclinical toxicity.
Objective: To determine the usefulness of the hepatobiliary, colloid and cardiac scintigraphies, employing
99mTcdisida,
99mTc-phytate and
99mTc-sestamibi respectively, in the evaluation of the hepato and cardiotoxicity of two
chemotherapeutic treatments assessed in rats.
Method: Two groups were submitted to doxorubicin (DOX) treatment and one was co-administered with histamine
(DOX+HIS). Static
99mTc-phytate and
99mTc-sestamibi scintigraphies as well as a dynamic
99mTc-disida study were
performed in a small field of view gamma camera at: 0 weeks (control), 1 week and 2 weeks of treatment.
Imagenological parameters were calculated: Liver/Bone Marrow ratio (L/BM), Heart/Background ratio (H/B) and time
to the maximum (Tmax) for 99mTc-phytate, 99mTc-sestamibi and 99mTc-disida extraction, respectively.
Results: Control (L/BM= 98±3; H/B=2.3±0.4; Tmax=8±3), DOX (L/BM: 85±3, 80±3; H/B, 3.5±0.5, 3.3±0.5 and
Tmax 6±1, 4±1) for 1 and 2 weeks respectively and DOX+HIS (L/BM: 99±0.3, 98±1; H/B 2.9±0.5, 2.9±0.5 and Tmax,
8±2, 9±2) for 1 and 2 weeks, respectively. Histological analysis showed cardio and hepatotoxicity induced by doxorubicin.
Conclusion: Imagenological parameters showed differences among treated and control groups and between both
chemotherapy treatments. Thus, these radiopharmaceutical functional approaches were able to reflect heart and liver
toxicity produced by doxorubicin.
