Title:Synthesis and Antimicrobial Activity of Mono, Bis and Tris 2-Amino-4HChromenes
Volume: 12
Issue: 10
Author(s): Mohammad Nikpassand, Leila Zare Fekri, Hanieh Badri and Leila Asadpour
Affiliation:
Keywords:
Antimicrobial, chromenes, ionic liquid, multicomponent reaction, α-Naphthol, malononitrile.
Abstract: A clean and environmentally benign route to 2-amino-4H-chromenes has been developed
using the reaction between various benzaldehydes, malononitrile and α-naphthol in the presence of
3,3'-(pentane-1,5-diyl)bis(1,2-dimethyl-1H-imidazol-3-ium) bromide. The present methodology offers
several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions
and reduced environmental consequences. The ionic liquid was recovered and reused. All of synthesized
compounds were characterized by IR, NMR and Elemental analyses.