Abstract
A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS cancer cell line for 1-cyanoindolizine derivative 10b. Moreover, a supplementary in vitro biological evaluation showed that compound 9d exhibited a significant farnesyltransferase inhibition activity (IC50 = 1.07 ± 0.34 µM) and could represent a lead for the development of new antitumoral chemical entities.
Keywords: Indolizine, farnesyltransferase, anticancer agent.
Letters in Drug Design & Discovery
Title:Synthesis and Biological Evaluation of Some New Indolizine Derivatives as Antitumoral Agents
Volume: 13 Issue: 6
Author(s): Liliana Lucescu, Elena Bîcu, Dalila Belei, Joelle Dubois and Alina Ghinet
Affiliation:
Keywords: Indolizine, farnesyltransferase, anticancer agent.
Abstract: A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS cancer cell line for 1-cyanoindolizine derivative 10b. Moreover, a supplementary in vitro biological evaluation showed that compound 9d exhibited a significant farnesyltransferase inhibition activity (IC50 = 1.07 ± 0.34 µM) and could represent a lead for the development of new antitumoral chemical entities.
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Cite this article as:
Lucescu Liliana, Bîcu Elena, Belei Dalila, Dubois Joelle and Ghinet Alina, Synthesis and Biological Evaluation of Some New Indolizine Derivatives as Antitumoral Agents, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/1570180812666151022221628
DOI https://dx.doi.org/10.2174/1570180812666151022221628 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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