Abstract
This work demonstrates the effective total synthesis of a new broad-spectrum parenteral carbapenem starting from the readily available and inexpensive N-Cbz-protected glycine amide in high yield with easy work-up under mild reaction conditions.
Keywords: Carbapenem, C-C coupling, diazo compound, glycine amide, ME1036, total synthesis.
Letters in Organic Chemistry
Title:Total Synthesis of ME1036 Starting from Readily Available Inexpensive Materials
Volume: 12 Issue: 10
Author(s): Zhi-Jian Han, Yang-Bing Li, Lu-Xi Yang, Ai-lin Song, Hao Chen and Yu-Min Li
Affiliation:
Keywords: Carbapenem, C-C coupling, diazo compound, glycine amide, ME1036, total synthesis.
Abstract: This work demonstrates the effective total synthesis of a new broad-spectrum parenteral carbapenem starting from the readily available and inexpensive N-Cbz-protected glycine amide in high yield with easy work-up under mild reaction conditions.
Export Options
About this article
Cite this article as:
Han Zhi-Jian, Li Yang-Bing, Yang Lu-Xi, Song Ai-lin, Chen Hao and Li Yu-Min, Total Synthesis of ME1036 Starting from Readily Available Inexpensive Materials, Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612666150924001523
DOI https://dx.doi.org/10.2174/1570178612666150924001523 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Using PK/PD to Optimize Antibiotic Dosing for Critically Ill Patients
Current Pharmaceutical Biotechnology Inflammatory Syndrome in Chronic Kidney Disease: Pathogenesis and Influence on Outcomes
Inflammation & Allergy - Drug Targets (Discontinued) Pharmacology of Cyclic Peptides: Vancomycin and Oxytocin as Paradigms
Protein & Peptide Letters Long-term Outcomes of Mitral Valve Repair Versus Replacement for Degenerative Disease: A Systematic Review
Current Cardiology Reviews Therapeutic Potential of Green Synthesized Metallic Nanoparticles Against <i>Staphylococcus aureus</i>
Current Drug Research Reviews Heart Failure in South America
Current Cardiology Reviews Alkaloids: An Emerging Antibacterial Modality Against Methicillin Resistant Staphylococcus aureus
Current Pharmaceutical Design MRSA Infections: From Classical Treatment to Suicide Drugs
Current Medicinal Chemistry Novel Perspective for Antithrombotic Therapy in TAVI
Current Pharmaceutical Design Outpatient Treatment of Hemorrhoidal Disease: The Alternative Way to Treat Hemorrhoidal Disease in a Simple, Safe and Effective Manner
Reviews on Recent Clinical Trials Fluoroquinolones: Blessings Or Curses
Current Drug Targets The First Years of Linezolid Experience in Clinical Practice: A Balance and Future Implications
Anti-Infective Agents in Medicinal Chemistry The Virulent Hypothetical Proteins: The Potential Drug Target Involved in Bacterial Pathogenesis
Mini-Reviews in Medicinal Chemistry Aspirin Resistance in Cardiovascular Disease: Pathogenesis, Diagnosis and Clinical Impact
Current Pharmaceutical Design Atherosclerotic and Non-Atherosclerotic Coronary Heart Disease in Women
Current Medicinal Chemistry Anti-MRSA Cephems: An Update
Current Medicinal Chemistry - Anti-Infective Agents Prevalence of Nasal Colonization with Staphylococcus aureus in Patients with Rheumatoid Arthritis
Current Rheumatology Reviews Orchestrating HIV Neutralization by Secondary Immune Response- Mediated Induction of RF Antibodies
Current Immunology Reviews (Discontinued) Therapeutic Modulation of Gut Microbiota: Current Clinical Applications and Future Perspectives
Current Drug Targets Levosimendan: A New Inodilatory Drug for the Treatment of Decompensated Heart Failure
Current Pharmaceutical Design