Synthesis, Characterization of Novel Morpholino-1, 3, 5-Triazinyl Amino Acid Ester Derivatives and their Anti-Proliferation Activities

Title:Synthesis, Characterization of Novel Morpholino-1, 3, 5-Triazinyl Amino Acid Ester Derivatives and their Anti-Proliferation Activities

Volume: 12 Issue: 10

Author(s): Ayman El-Faham and Yasser A. Elnakady

Affiliation:

Keywords: Amino acid ester, anti-profileration activities, s-triazine.

Abstract: Novel series of 2-(4-chloro,6-morpholino-1,3,5-triazin-2-yl) amino acid ester derivatives and 2-(4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid ester derivatives were synthesized using simple one pot method in acetone–water in the presence of K₂CO₃ as HCl scavenger. The products were obtained in high yields and purities as observed from their spectral data, elemental analyses and mass spectra. The anti-proliferation activities have been measured in MTT-Assay using two different cell lines the cervix carcinoma cell line (Hela), and the hepatocyte carcinoma (HepG2). The analysis showed that none of the prepared compounds showed growth inhibition activity on Hela cells. However only the 4-aminobenzoic ester derivatives showed a moderate inhibition effect on the hepatocellular carcinoma HepG2, the measured IC₅₀ values were 48µg mL^-1 and 39µg mL^-1, respectively.

Cite this article as:

El-Faham Ayman and Elnakady A. Yasser, Synthesis, Characterization of Novel Morpholino-1, 3, 5-Triazinyl Amino Acid Ester Derivatives and their Anti-Proliferation Activities, Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612666150709165843