![conference banner](/images/conference-banner.jpeg)
Abstract
Using various chromatography methods, five steroids and two brominated lipids (1-7), 3β- hydroxy-5-cholenic acid methyl ester, stigmasta-5,24(28)-dien-3β,29-diol, 24-methylenecholest-4-en- 3β,6β-diol, cholest-5-en-3β,7β-diol, 24-vinylcholest-5-en-3β,24-diol, xestospongiene A, and xestospongiene J, respectively, were isolated from the methanol extract of Vietnamese marine sponge Haliclona oculata (Linnaeus, 1759). Their structures were elucidated by 1D-, 2D-NMR, and ESI-MS spectra and in comparison with those reported in the literature. Compounds 1-4, 6, and 7 were reported from Chalinidae family for the first time. In addition, all compounds were evaluated for eight human cancer cell lines as HepG-2, KB, LU-1, MCF-7, LNCaP, HL- 60, SK-Mel2, and PC-3. As shown in results, compound 2 showed significant cytotoxic activities on KB and LU-1 cancer cell lines with the IC50 values ranging from 8.74 to 9.32 μM.
Keywords: Brominated lipid, cytotoxic, Haliclona oculata, steroid.
Letters in Organic Chemistry
Title:Cytotoxic Constituents from Vietnamese Marine Sponge Haliclona oculata (Linnaeus, 1759)
Volume: 12 Issue: 10
Author(s): Phan Van Kiem, Nguyen Thi Viet Thanh, Dan Thi Thuy Hang, Nguyen Thi Cuc, Nguyen Xuan Nhiem, Pham Hai Yen, Hoang Le Tuan Anh, Bui Huu Tai, Do Thi Thao and Chau Van Minh
Affiliation:
Keywords: Brominated lipid, cytotoxic, Haliclona oculata, steroid.
Abstract: Using various chromatography methods, five steroids and two brominated lipids (1-7), 3β- hydroxy-5-cholenic acid methyl ester, stigmasta-5,24(28)-dien-3β,29-diol, 24-methylenecholest-4-en- 3β,6β-diol, cholest-5-en-3β,7β-diol, 24-vinylcholest-5-en-3β,24-diol, xestospongiene A, and xestospongiene J, respectively, were isolated from the methanol extract of Vietnamese marine sponge Haliclona oculata (Linnaeus, 1759). Their structures were elucidated by 1D-, 2D-NMR, and ESI-MS spectra and in comparison with those reported in the literature. Compounds 1-4, 6, and 7 were reported from Chalinidae family for the first time. In addition, all compounds were evaluated for eight human cancer cell lines as HepG-2, KB, LU-1, MCF-7, LNCaP, HL- 60, SK-Mel2, and PC-3. As shown in results, compound 2 showed significant cytotoxic activities on KB and LU-1 cancer cell lines with the IC50 values ranging from 8.74 to 9.32 μM.
Export Options
About this article
Cite this article as:
Kiem Van Phan, Thanh Thi Viet Nguyen, Hang Thi Thuy Dan, Cuc Thi Nguyen, Nhiem Xuan Nguyen, Yen Hai Pham, Anh Le Tuan Hoang, Tai Huu Bui, Thao Thi Do and Minh Van Chau, Cytotoxic Constituents from Vietnamese Marine Sponge Haliclona oculata (Linnaeus, 1759), Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612999150923120855
DOI https://dx.doi.org/10.2174/1570178612999150923120855 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Lectin Techniques for Glycoproteomics
Current Proteomics Absorption, Disposition and Pharmacokinetics of Nanoemulsions
Current Drug Metabolism Arsenic Trioxide Targets miR-125b in Glioma Cells
Current Pharmaceutical Design Computational Studies Applied to Anti-inflammatory Drug Discovery: A Review
Current Organic Chemistry Natural Products as Anti-Invasive and Anti-Metastatic Agents
Current Medicinal Chemistry CYR61 Confers the Sensitivity to Aromatase Inhibitor Letrozole in ER Positive Breast Carcinoma
Current Cancer Drug Targets Generation, Subsets and Functions of Inducible Regulatory T Cells
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Opportunities and Challenges of Fluorescent Carbon Dots in Translational Optical Imaging
Current Pharmaceutical Design Regulation of EMT by Notch Signaling Pathway in Tumor Progression
Current Cancer Drug Targets The Pharmacological Pathways of GnRH Mediating the Inhibition of Mammary Tumours: Implications in Humans and Domestic Animals
Current Medicinal Chemistry Decreased Expression of Caveolin-1 and E-Cadherin Correlates with the Clinicopathologic Features of Gastric Cancer and the EMT Process
Recent Patents on Anti-Cancer Drug Discovery Applications of X-Ray Diffraction Imaging to Mammography
Recent Patents on Medical Imaging Synthesis of Monosulfated Lewis a Trisaccharide Library Through Sulfation of a Partial Protected Trisaccharide
Letters in Organic Chemistry Recent Advances in Colon Drug Delivery Technology
Drug Delivery Letters SERMs: Evolutionary Chemistry, Revolutionary Biology
Current Pharmaceutical Design Roles of Medicinal Plants and Constituents in Gynecological Cancer Therapy: Current Literature and Future Directions
Current Topics in Medicinal Chemistry Prospective Clinical Applications of CRF Peptide Antagonists
Current Molecular Pharmacology Targeting the Tumor Proteasome as a Mechanism to Control the Synthesis and Bioactivity of Matrix Macromolecules
Current Molecular Medicine Genetic Modification of Natural Killer Cells for Leukemia Therapies
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Viral Vectors for Cancer Gene Therapy: Viral Dissemination and Tumor Targeting
Current Gene Therapy