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Abstract
A highly efficient and environmentally benign protocol for the synthesis of 8-amino-6-aryl-1,2-dihydro-2-oxo-6H-pyrano[2,3-e]benzoxazole-7-carbonitrile derivatives by one-pot three-component coupling reacting of aromatic aldehydes, malononitrile and 4-hydroxy-2(3H)-benzoxazolone under reflux condition has been developed in aqueous media using Na2O-Al2O3-P2O5 glass-ceramic system.
Keywords: 4-hydroxy-2(3H)-benzoxazolone, Acanthus ilicifolius alkaloid, aqueous media, glass-ceramic system, Na2O-Al2O3-P2O5, pyrano[2, 3-e]benzoxazoles.
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