Title:Polymeric Nanocarriers for Drug Delivery in Osteosarcoma Treatment
Volume: 21
Issue: 36
Author(s): Xueyuan Gu, Jianxun Ding, Zhiyu Zhang, Qin Li, Xiuli Zhuang and Xuesi Chen
Affiliation:
Keywords:
Active targeting, controlled drug delivery, osteosarcoma therapy, passive targeting, polymeric nanocarriers.
Abstract: Osteosarcoma (OS) is one of the most serious malignancies along with a high incidence in children and
teenagers. Although the neoadjuvant chemotherapy of OS has made great progress and prolongs the five-year survival
rates of patients to some extent, drugs are restrained from clinical application due to the unsatisfactory efficacy
and severe side effects, especially for the systemic therapy through intravenous injection. The polymeric
nanoparticles as anti-cancer drug nanocarriers make OS treatment more promising and effective. Specifically, various
polymeric nanoparticles have been developed to overcome the difficulties in targeting delivery of drugs to OS
tissue and/or cells through passive and/or active strategies. This review presents an overview on the development
of polymeric nanoparticles for anti-cancer drug delivery in OS treatment, and briefly describes the challenge and opportunity for future
development.