Title:Nutritional Status and Lipid Profile in HIV-Infected Adults
Volume: 15
Issue: 4
Author(s): M. Stambullian, M. S. Feliu, L. I. Cassetti and N. H. Slobodianik
Affiliation:
Keywords:
Adults, apolipoprotein B, HIV infection, lipids, non-HDL cholesterol, obesity, overweight.
Abstract: In the last decades, there have been many reports of HIV infection and abnormalities in
lipid metabolism and cardiovascular disease (CVD). This study aims at describing the nutritional
status of HIV-infected adults and its relation to lipid profile through traditional [total cholesterol
(TC), HDL cholesterol (HDL), triglycerides (TG), non-HDL cholesterol and LDL cholesterol (LDL)]
and other parameters [Apolipoprotein B (ApoB), fibrinogen, and high sensitive-C-reactive protein
(hs-CRP)].
A cross-sectional descriptive study was performed. Body mass index (BMI) was calculated and references were taken
from WHO. TC, HDL, TG and glucose were determined and non-HDL cholesterol and LDL were calculated. ApoB and
fibrinogen were determined by quantitative radial immunodiffusion on agar plates (Diffuplate,Biocientífica SA,Argentina)
and hs-CRP by immunoturbidimetric test. Qualitative variables were compared with the Chi-square test or Fisher's exact
test. Quantitative variables were compared applying parametrics or nonparametric tests. Pearson test for correlations.
Software SPSS 17.0. 97 patients were analyzed: 69.1% were men. 80% were on antiretroviral treatment. Average (SD)
BMI was 24.3 (4.1) kg/m2. 29.4% were overweight and 5.9% obese. Patients with a BMI ≥25.0 kg/m2 presented
significantly higher levels of TG, ApoB and glycemia than well-nourished people [246.1(169.0) vs. 142.9(78.4)
mg/dL;p=0.029, 198.6(69.3) vs. 126.4(50.6) mg/dL;p=0.01 and 100 (3.2) vs. 90.2 (6.9) mg/dL;p=0.008 resp.] and a
significantly decreased HDL [37.2(1.5) vs. 49.8(10.4) mg/dL;p<0.01]. No statistically significant correlation was found
between ApoB and non-HDL (p=0,063). There was no evidence that there is a direct relation between Apo B and the other
lipid parameters. The potential increase in CVD in this group of patients, would be related to the higher levels of TG,
ApoB and overweight/obesity. Nutritional education is needed to promote a healthy weight to warn against the risk of
cardiovascular disease.