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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

SNC 80 and Related δ Opioid Agonists

Author(s): S. N. Calderon and A. Coop

Volume 10, Issue 7, 2004

Page: [733 - 742] Pages: 10

DOI: 10.2174/1381612043453054

Price: $65

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Abstract

The discovery of the selective delta (δ) opioid agonists SNC 80 and BW373U86, which possess a diarylmethylpiperazine structure unique among opioids, was a major advance in the field of δ-opioid ligands. Much research has been performed to uncover the structure-activity relationships (SAR) of this class of ligands and also to compare the diarylmethylpiperazines with the traditional morphinan-based d opioids. This review focuses on the development of the SAR of this unique series of ligands, and discusses questions which remain unanswered.

Keywords: diarylmethylpiperazine, BW373U86


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