Title:Therapeutic Effects of Melatonin On Liver And Kidney Damages In Intensive Exercise Model of Rats
Volume: 15
Issue: 4
Author(s): Semin Gedikli, Volkan Gelen, Emin Sengul, Seckin Ozkanlar, Cihan Gur, Ozturk Agırbas, Fatih Cakmak and Adem Kara
Affiliation:
Keywords:
Apoptosis, exercise stress, kidney, liver, melatonin, rats.
Abstract: Extensive exercise induces inflammatory reactions together with high production of free
radicals and subsequent liver and kidney tissues damage. This study was designed to investigate for
effects of melatonin on liver and kidney tissues in the extensive exercise exposed rats and non-exercised rats.
In this research, 24-male Sprague-Dawley rats were divided into four groups. For exercise rat model, the rats were
exposed to slow pace running with the velocity of 10 m/min for 5 minutes for five days just before the study. And for last
ten days after adaptation period, the exercise was improved as 15 min with the speed of 20 m/min and intra-peritoneal
melatonin injection has been performed to the melatonin treated groups with the dose of 10 mg/kg.
Biochemical results revealed a decrease in the parameters of kidney and liver enzymes in exercise-group and an increase
in the parameters of serum, liver and kidney enzymes in the group that melatonin-exercise-group. As for histological
analysis, while it is observed that there are cellular degenerations in the liver and kidney tissues with exercise application,
a decrease has been observed in these degenerations in the group that melatonin was applied.
At the end of the research, it has been determined that exercise application causes some damages on liver and kidney, and
these damages were ameliorated with melatonin treatment.
