Title:Coffee and Depression: A Short Review of Literature
Volume: 21
Issue: 34
Author(s): Gian Carlo Tenore, Maria Daglia, Valentina Orlando, Emanuela D'Urso, Seyed Hassan Saadat, Ettore Novellino, Seyed Fazel Nabavi and Seyed Mohammad Nabavi
Affiliation:
Keywords:
Adverse effects, bioactive compounds, clinical impacts, coffee, depression.
Abstract: Coffee is among the most widespread and healthiest beverages in the world. It is known to be a highly
rich source of biologically active natural metabolites which possess therapeutic effects (i.e. caffeine) and functional
properties (i.e. chlorogenic acids). Therefore, coffee can be considered a drink which has different positive
effects on human health such as cardioprotective, neuroprotective, hepatoprotective, nephroprotective, etc. However,
heavy coffee consumption may be related to some unpleasant symptoms, mainly anxiety, headache, increased
blood pressure, nausea, and restlessness. During the past two decades, several studies have indicated that there is a close correlation between
consumption of coffee and incidence of depression. In addition, phytochemical studies showed that caffeine is the main responsible
constituent for antidepressant effects of coffee through multiple molecular mechanisms. The aim of the present paper was to collect
the latest literature data (from 1984 to 2014) on the positive and negative impacts of coffee consumption on the major depressive disorders
and to clarify the role of bioactive constituents of coffee in the related different clinical trials. To the best of our knowledge, this the
first review on this topic.
