Title:Polysaccharide-Based Nanocarriers for Ocular Drug Delivery
Volume: 21
Issue: 33
Author(s): Maria Lina Formica, Javier Adrian Calles and Santiago Daniel Palma
Affiliation:
Keywords:
Gene therapy, nanocarriers, nanoparticles, ocular barriers, ocular drug delivery, polysaccharides.
Abstract: Obtaining successful ocular formulations able to support an efficient drug concentration at the target tissue
for an appropriate period of time is an interesting challenge for modern pharmaceutical technology. In this
sense, nanotechnology is one of the available strategies to obtain a drug carrier system that allows access to different
compartments of the eye in order to deliver drugs to the desired site. Biodegradable polymers such as polysaccharides
are promising biomaterials for the production of biocompatible and biodegradable nanocarriers (NCs).
Different types of polysaccharide NCs are capable of improving the transport of drugs after ocular application and
they can be either polysaccharide-matrix carriers or polysaccharide-coated carriers, depending on whether polysaccharide is used as a
matrix or as a coating, respectively. This review focuses on recent advances achieved by polysaccharide-based NCs for the treatment of
ocular disorders.
