Cytotoxic Effects on B Lymphocytes Mediated by Reactive Oxygen Species

Neus      Villamor; Emili      Montserrat; Dolors      Colomer

doi:10.2174/1381612043452848

Abstract

Reactive oxygen species (ROS) are produced in all mammalian cells as a result of normal cellular metabolism and due to the activation of oxidant-producing enzymes in response to exogenous stimuli. The balance between ROS production and antioxidant defenses determines the degree of oxidative stress. Generation of ROS has been associated with cell signaling, stress responses, cell proliferation, aging and cancer development. The ability of ROS to induce cellular damage and to cause cell death opens the possibility to exploit this property in the treatment of cancer through a free radical-mediated mechanism.

Keywords: ros, b cells, lymphoproliferative disorders, rituximab, 2-methoxyoestradiol, imexon, arsenic trioxide 1, 4- benzodiazepine