Abstract
Natural products are recent emerging effective agents against many chronic human diseases. Curcumin (diferuloylmethane), the active constituent of turmeric (Curcuma longa), has gained much interest as a plant-based compound with pleiotropic biological activities. Curcumin has been shown to possess significant anti-oxidant, anti-carcinogenic, anti-inflammatory, and anti-microbial effects. Although the history of curcumin goes back thousands of years, the mechanism involved behind medicinal role of curcumin remains a topic of debate. In addition to this, its stability, solubility and bioavailability issues create reasons for further researches on this yellow molecule. Present article provides an overview of the history, chemistry, biological effects, and an update of mechanism(s) of action of curcumin.
Keywords: Curcumin, antioxidant, biological activities, bioavailability.
Letters in Drug Design & Discovery
Title:Curcumin: the Yellow Molecule with Pleiotropic Biological Effects
Volume: 13 Issue: 2
Author(s): Prabhakar Singh, Kanti Bhooshan Pandey and Syed Ibrahim Rizvi
Affiliation:
Keywords: Curcumin, antioxidant, biological activities, bioavailability.
Abstract: Natural products are recent emerging effective agents against many chronic human diseases. Curcumin (diferuloylmethane), the active constituent of turmeric (Curcuma longa), has gained much interest as a plant-based compound with pleiotropic biological activities. Curcumin has been shown to possess significant anti-oxidant, anti-carcinogenic, anti-inflammatory, and anti-microbial effects. Although the history of curcumin goes back thousands of years, the mechanism involved behind medicinal role of curcumin remains a topic of debate. In addition to this, its stability, solubility and bioavailability issues create reasons for further researches on this yellow molecule. Present article provides an overview of the history, chemistry, biological effects, and an update of mechanism(s) of action of curcumin.
Export Options
About this article
Cite this article as:
Singh Prabhakar, Pandey Bhooshan Kanti and Rizvi Ibrahim Syed, Curcumin: the Yellow Molecule with Pleiotropic Biological Effects, Letters in Drug Design & Discovery 2016; 13 (2) . https://dx.doi.org/10.2174/1570180812666150630184101
DOI https://dx.doi.org/10.2174/1570180812666150630184101 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
Call for Papers in Thematic Issues
Navigating the Frontier: Probiotics' Promising Path in Combatting Viral Respiratory Infections, Spotlight on Coronaviridae.
Probiotics, well-known for their role in gut health, show promise in preventing and managing respiratory virus infections, particularly in children and at-risk populations. However, the profound influence of novel pathogenic viral RTIs such as coronaviruses has reshaped perspectives on the potential of probiotics. Despite their potential, significant gaps remain in ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Endothelial Cell Regulation of Cardiac Metabolism Following Diabetes
Cardiovascular & Hematological Disorders-Drug Targets The Role of Blood-Brain Barrier Transporters in Pathophysiology and Pharmacotherapy of Stroke
Current Pharmaceutical Design Biochemical, Biomedical and Metabolic Aspects of Imidazole-Containing Dipeptides with the Inherent Complexity to Neurodegenerative Diseases and Various States of Mental Well-Being: A Challenging Correction and Neurotherapeutic Pharmaceutical Biotechnology for Treating Cognitive Deficits, Depression and Intellectual Disabilities
Current Pharmaceutical Biotechnology Medical Applications of Implantable Drug Delivery Microdevices Based on MEMS (Micro-Electro-Mechanical-Systems)
Current Pharmaceutical Biotechnology The Reno-Protective Effect of the Dual Blockade of the Renin Angiotensin System (RAS)
Current Pharmaceutical Design Molecular and Biochemical Changes of the Cardiovascular System due to Smoking Exposure
Current Pharmaceutical Design Alzheimer's Disease and Chinese Medicine as a Useful Alternative Intervention Tool: A Mini-Review
Current Alzheimer Research Novel Therapeutic Options for Chagas Disease Based on Bioactive Compounds from Algae, Bacteria and Fungi Species
Current Medicinal Chemistry Molecular Signals Elicited by GPCR Agonists in Hypertension, Cardiovascular Remodeling: Are MMPs and ADAMs Elusive Therapeutic Targets?
Current Hypertension Reviews Will Sodium Intake Reduction Improve Cardiovascular Outcomes in the General Population? A Critical Review of Current Evidence
Current Hypertension Reviews Chronopharmaceutical Delivery of Anti-Inflammatory Drugs
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Malnutrition in Patients with End-Stage Renal Disease - Anorexia,Cachexia and Catabolism
Current Nutrition & Food Science Probiotics as Biotherapeutic Agents: Present Knowledge and Future Prospects
Current Pharmaceutical Design Life-Threatening Respiratory Syncytial Virus Disease in Children
Current Respiratory Medicine Reviews Uric Acid in Metabolic and Cerebrovascular Disorders: A Review
Current Vascular Pharmacology Non Steroidal Estrogen Antagonists: Current Status and Future Perspectives
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Multiple, Extensive Cardiac and Pulmonary Hydatid Cysts Managed by a Single-stage Surgical Removal: A Case Report
New Emirates Medical Journal Pharmacogenetics of the Antiplatelet Effect of Aspirin
Current Pharmaceutical Design Analysis of Adherence to anti-PCSK9 Antibody Therapy among Patients from Italy
Cardiovascular & Hematological Disorders-Drug Targets Qualitative Analysis and Anti-oxidant Potential of Ethanolic Extract of <i>Manilkara zapota (L.) P. Royen</i> Leaves
Applied Drug Research, Clinical Trials and Regulatory Affairs