摘要
外周动脉疾病(PAD)是一种由动脉粥样硬化引起的炎症性疾病。已表明PAD与慢性炎症有关。尽管传统风险因素导致PAD的发病和发展,涉及PAD的新型炎症标记物的作用已被逐渐认识。PAD的新型生物标记物使得可以早期的筛查和检测、抑制疾病进程和开发新疗法。本文总结了有助于PAD治疗的诊断、预后和途径的炎症生物标记物。
关键词: 生物标记物,诊断,外周动脉疾病,预后,治疗。
Current Medicinal Chemistry
Title:Inflammatory Biomarkers in Peripheral Artery Disease: Diagnosis, Prognosis, and Therapeutic Challenges
Volume: 22 Issue: 23
Author(s): Yuichi Ozaki, Toshio Imanishi and Takashi Akasaka
Affiliation:
关键词: 生物标记物,诊断,外周动脉疾病,预后,治疗。
摘要: Peripheral artery disease (PAD) is an inflammatory disease caused by atherosclerosis. It has been demonstrated that PAD is related to chronic inflammation. While conventional risk factors lead to the pathogenesis and progression of PAD, the role of novel inflammatory biomarkers in relation to PAD is being increasingly recognized. The novel biomarkers for PAD may allow for earlier screening and detection, suppression of disease progression, and development of new therapeutic approaches. In this review, inflammatory biomarkers that should be contributory to diagnosis, prognosis, and avenues for therapeutic challenges in PAD are summarized.
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Yuichi Ozaki, Toshio Imanishi and Takashi Akasaka , Inflammatory Biomarkers in Peripheral Artery Disease: Diagnosis, Prognosis, and Therapeutic Challenges, Current Medicinal Chemistry 2015; 22 (23) . https://dx.doi.org/10.2174/0929867322666150630141200
DOI https://dx.doi.org/10.2174/0929867322666150630141200 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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