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摘要
非对称二甲基精氨酸(ADMA)是一种内源性一氧化氮合酶竞争性抑制剂,它是一种血管内皮功能失调的关键因子,同时和动脉粥样硬化和心血管疾病发生发展密切相关。他汀类药物、肾素-血管紧张素-醛固酮系统抑制剂、降血糖药、胰岛素增敏剂、β受体阻滞剂、雌激素替代疗法、抗氧化剂、复合维生素B、L-精氨酸和乙酰水杨酸都已评估它们降低ADMA水平或抑制其活性的能力。尽管这些药物主要用于治疗心血管疾病,然而有研究表明,它们良好的活性仅仅通过降低ADMA水平或避开一氧化氮合成介导发挥作用。靶向选择性ADMA新的治疗方法是令人振奋的,但现在只进行了体外实验或动物实验,而通过调节ADMA活性来治疗动脉粥样硬化和心血管疾病的策略,如何得到这一结论还需要进一步的研究。
关键词: 非对称二甲基精氨酸,动脉粥样硬化,心血管疾病,一氧化氮,治疗方法
Current Medicinal Chemistry
Title:Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches
Volume: 22 Issue: 24
Author(s): Dimitris Tousoulis, Marios K. Georgakis, Evangelos Oikonomou, Nikolaos Papageorgiou, Marina Zaromitidou,, George Latsios, Spyridon Papaioannou and Gerasimos Siasos
Affiliation:
关键词: 非对称二甲基精氨酸,动脉粥样硬化,心血管疾病,一氧化氮,治疗方法
摘要: Asymmetric dimethylarginine (ADMA) is a competitive endogenous inhibitor of nitric oxide synthase with a key role in the pathophysiology of endothelial dysfunction, in the progression of atherosclerosis and in cardiovascular diseases. Statins, renin-angiotensin-aldosterone system inhibitors, blood glucose lowering agents, insulin sensitizers, beta-blockers, estrogen replacement therapy, antioxidants, complex B vitamins, L-arginine and acetylsalicylic acid have been evaluated for their ability to reduce ADMA levels or inhibit its actions. Despite the major beneficial effects of these agents in cardiovascular disease, research has shown that their favorable actions are only partially mediated by reducing ADMA levels or by bypassing its effect in nitric oxide synthesis. Novel therapeutic approaches targeting selectively ADMA are encouraging, but have only been tested in vitro or in animal studies and further research is needed in order to conclude on how therapeutic strategies modulating ADMA actions can affect atherosclerosis progression and cardiovascular diseases.
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Dimitris Tousoulis , Marios K. Georgakis , Evangelos Oikonomou , Nikolaos Papageorgiou , Marina Zaromitidou, , George Latsios , Spyridon Papaioannou and Gerasimos Siasos , Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches, Current Medicinal Chemistry 2015; 22 (24) . https://dx.doi.org/10.2174/0929867322666150625095046
DOI https://dx.doi.org/10.2174/0929867322666150625095046 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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