杂环氮氧化物-一类新兴药

Title:Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents

Volume: 22 Issue: 24

Author(s): A.M. Mfuh and O.V. Larionov

Affiliation:

关键词: 杂环氮氧化物，一氧化氮模拟物，生物电子等排体，低氧血症，Xa因子抑制剂，凝血-级联型直接凝血酶抑制剂，抗南美洲锥虫病药，抗疟药

摘要: Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and procognitive activities. The N-oxide motif has been successfully employed in a number of recent drug development projects. This review surveys the emergence of this scaffold in the mainstream medicinal chemistry with a focus on the discovery of the heterocyclic N-oxide drugs, N-oxide-specific mechanisms of action, drug-receptor interactions and synthetic avenues to these compounds. As the first review on this subject that covers the developments since 1950s to date, it is expected that it will inspire wider implementation of the heterocyclic N-oxide motif in the rational design of new medicinal agents.

Cite this article as:

A.M. Mfuh and O.V. Larionov , Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents, Current Medicinal Chemistry 2015; 22 (24) . https://dx.doi.org/10.2174/0929867322666150619104007