Abstract
Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and procognitive activities. The N-oxide motif has been successfully employed in a number of recent drug development projects. This review surveys the emergence of this scaffold in the mainstream medicinal chemistry with a focus on the discovery of the heterocyclic N-oxide drugs, N-oxide-specific mechanisms of action, drug-receptor interactions and synthetic avenues to these compounds. As the first review on this subject that covers the developments since 1950s to date, it is expected that it will inspire wider implementation of the heterocyclic N-oxide motif in the rational design of new medicinal agents.
Keywords: Heterocyclic N-oxides, nitric oxide mimics, bioisosteres, hypoxia, factor Xa inhibitors, coagulation cascade direct thrombin inhibitors, antichagasic agents, antimalarials.
Current Medicinal Chemistry
Title:Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents
Volume: 22 Issue: 24
Author(s): A.M. Mfuh and O.V. Larionov
Affiliation:
Keywords: Heterocyclic N-oxides, nitric oxide mimics, bioisosteres, hypoxia, factor Xa inhibitors, coagulation cascade direct thrombin inhibitors, antichagasic agents, antimalarials.
Abstract: Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and procognitive activities. The N-oxide motif has been successfully employed in a number of recent drug development projects. This review surveys the emergence of this scaffold in the mainstream medicinal chemistry with a focus on the discovery of the heterocyclic N-oxide drugs, N-oxide-specific mechanisms of action, drug-receptor interactions and synthetic avenues to these compounds. As the first review on this subject that covers the developments since 1950s to date, it is expected that it will inspire wider implementation of the heterocyclic N-oxide motif in the rational design of new medicinal agents.
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Cite this article as:
Mfuh A.M. and Larionov O.V., Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents, Current Medicinal Chemistry 2015; 22 (24) . https://dx.doi.org/10.2174/0929867322666150619104007
DOI https://dx.doi.org/10.2174/0929867322666150619104007 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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